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Meta-analysis of the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation

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DOI: 10.23977/medcm.2023.050408 | Downloads: 7 | Views: 476

Author(s)

Yanrong Zhan 1, Xianwen Cheng 2, Yan Ou 1, Jiyun Wu 1, Yaping Cui 3

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Ankang Traditional Chinese Medicine Hospital, Ankang, Shaanxi, 725000, China
3 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Xianwen Cheng

ABSTRACT

Objective: To systematically evaluate the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation. Methods: From PubMed, Embase, Web of Science and Cochrane Library to December 2022, the qualified research was screened in strict accordance with the nanofiltration standard. The Cochrane bias risk assessment method and the modified Jadad scale were used to evaluate the quality of literature, and the meta-analysis was carried out using stata 15.0 software. Results: 16 clinical randomized controlled trials were finally included, with a total of 1099 patients. Meta-analysis shows that Chinese medicine can effectively promote bifidobacteria (SMD=0.95, 95% CI (0.78-1.12), Z=10.79, P=0.000<0.05), lactobacillus (SMD=0.61, 95% CI (0.25 - 0.98), Z=3.26, P=0.001<0.05), lactobacillus (SMD=0.72, 95% CI (0.42 - 1.03), Z=4.68, P=0.000<0.05) and gram-positive bacilli (SMD=2.12, 95% CI (1.65, 2.59), Z=8.90, P=0.000<0.05) in the intestine of constipation patients), It can inhibit Escherichia coli (SMD=-0.46, 95% CI (-0.66, -0.27), Z=4.69, P=0.000<0.05), enterobacteria (SMD=-0.86, 95% CI (-1.08, -0.64), Z=7.67, P=0.000<0.05), enterococcus (SMD=-0.42, 95% CI (-0.62, -0.22), Z=4.14, P=0.000<0.05), yeast (SMD=-0.94, 95% CI (-1.28, -0.59), Z=5.32, P=0.000<0.05) and gram negative cocci (SMD=-0.68, 95% CI (-1.23, -0.15), Z=2.50, P=0.012<0.05). There is no significant difference between traditional Chinese medicine and western medicine in terms of gram-negative bacilli (SMD=-0.19, 95% CI (-0.56,0.18), Z=1.02, P=0.306>0.05), gram-positive cocci (SMD=-0.23, 95% CI (-0.60,0.13), Z=1.26, P=0.208>0.05), and cocci ratio (SMD=1.32, 95% CI (-0.22,1.16), Z=1.92, P=0.186>0.05). In addition, traditional Chinese medicine can reduce the intestinal PH value of constipation patients (SMD=-0.85, 95% CI (-1.11, -0.59), Z=6.38, P=0.000<0.05), and keep the intestinal micro-ecological environment in balance. Conclusion: Compared with western medicine, traditional Chinese medicine has more advantages in regulating intestinal flora of constipation patients.

KEYWORDS

Chinese medicine; Intestinal flora; Constipation; Meta-analysis

CITE THIS PAPER

Yanrong Zhan, Xianwen Cheng, Yan Ou, Jiyun Wu, Yaping Cui, Meta-analysis of the regulatory effect of traditional Chinese medicine on intestinal flora in patients with constipation. MEDS Chinese Medicine (2023) Vol. 5: 50-63. DOI: http://dx.doi.org/10.23977/medcm.2023.050408.

REFERENCES

[1] Qiang Rui. Progress in the treatment of constipation with traditional Chinese and western medicine [J]. Chinese Journal of Anorectal Diseases, 2019, 39 (09): 77-78.
[2] Tang Weifeng, Tang Xiaojun, Yang Wei. Research progress of functional constipation in traditional Chinese and western medicine [J]. Integrated Traditional Chinese and Western Medicine in the World.
[3] Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, anutrient in red meat, promotes atherosclerosis [J]. Nat Med, 2013, 19 (5):576-585.
[4] Dinan TG, Cryan JF. Gut-brain axis in 2016: braingut-microbiota axis-mood, metabolism and behaviour [J]. Nat Rev Gastroenterol Hepatol, 2017, 14 (2):69-70.
[5] Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions [M]. Wiley Online Library 2008. 
[6] Jadad A R, Moore R A, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary?[J]. Controlled Clinical Trials, 1996, 17(1):1-12.
[7] Zhu Yeshan, Lu Qingge, Li Fenghong, Li Xiaohai, Hu Ze, Chen Tongjun, Bai Guomin, Wang Qingxian. Randomized controlled clinical study on 36 patients with heat accumulation functional constipation treated with turbid detoxification Runchang Formula [J]. Journal of Traditional Chinese Medicine, 2022,63 (09): 845-850. DOI: 10. 13288/ j.11-2166/r.2022.09.010.
[8] Zhang Desheng, Li Yiliang, Liu Shuichun, Zhou Peirong, Sun Shaoqiu. Clinical study on the treatment of constipation after internal fixation of lumbar spine with Shengxue Tongbian granules combined with sodium docurate tablets [J]. Chinese Journal of Traditional Chinese Medicine Information, 2021,28 (04): 107-111. DOI: 10. 19879/ j. cnki. 1005-5304.202008424.
[9] Li Jie. The efficacy of Jiezhuo Jiedu Tongbian Formula in the treatment of functional constipation due to heat accumulation and its effect on intestinal bacterial count [D]. North China University of Technology, 2021. DOI: 10. 27108/ d.cnki.ghelu.2021.000501.
[10] He Yu, An Xiaohai, Tang Lingjiao. Clinical study of modified Huangqi decoction combined with compound lactobacillus acidophilus in the treatment of constipation due to qi deficiency after chemotherapy [J]. Chinese Journal of Integrated Traditional and Western Medicine Digestion, 2021,29 (07): 497-501.
[11] ZHANG Guiying, XU Sheng, LU Canxing, SHI Jian. Clinical Observation of Zhipu Jieyu Decoction Combined with Polyethylene Glycol Electrolyte Powder(Ⅳ)on Chronic Functional Constipation [J]. Clinical Journal of Traditional Chinese Medicine, 2020, 32(12):2321-2325.
[12] Yang Feng, Chen Weiwei, Xie Meimei, etc. The regulatory effect of Yuan Xingshi's prescription "Jichuan Yanshou Ointment" on intestinal neurotransmitter and intestinal flora in patients with functional constipation with spleen and kidney yang deficiency syndrome [J]. Journal of Modern Integrated Chinese and Western Medicine, 2020, 29 (4): 371-375 DOI:10.3969/j.issn.1008-8849.2020.04.008.
[13] Ma Yan. Clinical study of Linggu mixture on intestinal flora changes in patients with functional constipation [D]. Shandong University of Traditional Chinese Medicine, 2020. DOI: 10.27282/d.cnki.gsdzu.2020.000828.
[14] Zhang Huan, Yin Kejing, Liu Xueli, Zhang Miao, Ren Huifeng, Zhou Hongwei, Lei Bianting, Qin Qingyun. Clinical efficacy observation of modified Xiaojianzhong decoction on patients with chronic heart failure and constipation [J]. Journal of Shaanxi University of Traditional Chinese Medicine, 2019, 42 (06): 117-119+138. DOI: 10. 13424/ j.cnki.jsctcm.2019.06.031.
[15] Li Beiting. Observation on the changes of intestinal flora and clinical efficacy of Changrunfang in the treatment of functional constipation patients with qi stagnation and fluid deficiency [D]. Fujian University of Traditional Chinese Medicine, 2019.
[16] Zhang Shuangxi, Zhang Xiang'an, An Yongkang. Effect of Jichuan Decoction on gastrointestinal function, serum intestinal neurotransmitter and intestinal flora in elderly patients with chronic functional constipation [J]. Chinese Journal of Experimental Prescriptions, 2018,24 (22): 169-174. DOI: 10.13422/j.cnki.syfjx.20182131.
[17] Yu Shaolei. Clinical study on the effect of Huangqi Runchang pill on regulating the proportion of intestinal flora in constipation patients [D]. Heilongjiang University of Traditional Chinese Medicine, 2015.
[18] Pan Yan. Clinical study on the effect of Yiqi Yangyin Tongbian Decoction on intestinal flora and NO in patients with constipation due to deficiency of both qi and yin [D]. Nanjing University of Traditional Chinese Medicine, 2007.
[19] Li Yaqi. Clinical study on the treatment of chronic functional constipation (liver depression type) with self-prepared Shugan Xingqi decoction to improve intestinal flora [D]. Shandong University of Traditional Chinese Medicine, 2020. DOI: 10.27282/d.cnki.gsdzu.2020.000090.
[20] Xiao Changfang. Clinical study on the treatment of functional constipation with traditional Chinese medicine compound combined with micro-ecological regulator and its effect on the regulation of intestinal flora [D]. Shanghai University of Traditional Chinese Medicine, 2019. DOI: 10.27320/d.cnki.gszyu.2019.000666.
[21] Duan Xiaoxin. Clinical observation on the effect of Yiqi Jianpi Tongbian Formula on the patients with lung and spleen deficiency slow transit constipation and its influence on the changes of intestinal flora [D]. Anhui University of Traditional Chinese Medicine, 2022. DOI: 10.26922/d.cnki.ganzc.2022.000112.
[22] Tian Jun, Li Chuanyan, Zhang Jianming, Xia Lianghui, Tang Xiaojun, Wan Xiaoli. Effect of Yiqi Yangyin Tongbian Decoction on intestinal flora of constipation patients with deficiency of both qi and yin [J]. Chinese Journal of Anorectal Diseases, 2021,41 (03): 47-49.
[23] Wu Boqian, Zhang Hongxi. Research progress on the effect of traditional Chinese medicine on constipation on intestinal flora [J/OL]. Chinese Journal of Traditional Chinese Medicine: 1-14 [2023-02-02] http: // kns. cnki. net/ kcms/ detail/21.1546.R.20221205.1501.008.html.
[24] Hong Yanqiu, Zhang Shuxin, Xiao Qiuping, Lin Jinrong, Geng Xuesi. Clinical study on the regulation of intestinal flora in patients with functional constipation by Changrun Formula [J]. Hebei Journal of Traditional Chinese Medicine, 2021, 36 (04): 13-17. DOI: 10.16370/j.cnki. 13-1214/r.2021.04.004.
[25] Liu Yong, Gu Nonuo, Wang Kaixing, et al. Effect of Tongfu Jiangzhuo Formula on the structure of fecal flora in rats with constipation irritable bowel syndrome [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2020, 37 (6): 1127-1133.
[26] Li Haibo, Shi Yu, Zhang Hongxi. Study on the regulatory effect of Zhuyang Tongbian Ointment on intestinal flora and barrier function of rats with constipation [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 37 (07): 1714-1717. DOI: 10.13193/j.issn.1673-7717.2019.07.043.
[27] Shao Jianning, Zhang Wenqi, Ma Heping, et al Study on optimization of bifidobacterium culture medium and pH regulation culture [J]. China Brewing, 2010 (3): 122-124 DOI: 10. 3969/j. issn. 0254-5071. 2010. 03. 036.
[28] Jiang Xiuju. Clinical and intervention of intestinal microecological disorders [J]. Chinese Journal of Microbiology, 2002, 14 (2): 108.

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