Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Public Health and Preventive Medicine
  4. Vol 3, Issue 1, 2023

Exercise Intervention Regulates Fibroblast Growth Factor 21: A Systematic Review and Meta-analysis

Download as PDF

DOI: 10.23977/phpm.2023.030107 | Downloads: 7 | Views: 401

Author(s)

Peilun Li 1, Jinglin Huang 1

Affiliation(s)

1 Guangzhou Sport University, No.1258 Guangzhou Avenue Middle, Tianhe District, Guangzhou, 510000, China

Corresponding Author

Peilun Li

ABSTRACT

To clarify the change of fibroblast growth factor 21 (FGF21) concentration in circulating blood induced by exercise intervention in adults, this meta-analysis was designed. PubMed, Medline, and Web of Science databases were searched until July 18, 2022. Two authors work independently, including literature screening, data extraction and quality assessment. RevMan 5.3 and StataSE 15 software were used to data analysis. Eleven studies were eventually included. Compared with the control group, after exercise intervention [SMD = -0.63, 95% CI: -1.17 to -0.08, P = 0.02], the concentration of plasma FGF21 in adults was increased significantly more than control group. Subgroup analysis showed that the effect size was significant in diseased populations [SMD = -1.51, 95% CI: -2.89 to -0.13, P = 0.03]. Regardless of the subjects’ BMI, the results showed statistical differences. The effect size was larger in those with BMI ≥ 28 [SMD = -1.91, 95% CI: -2.91 to -0.91, P = 0.0002] and smaller in those with BMI < 28 [SMD = 0.32, 95% CI: -0.01 to -0.65, P = 0.05]. The promotion of FGF21 concentration by exercise was also correlated with age. When the age of the subjects was equal to and greater than 40 years old, the effect size was significant [SMD = -1.20, 95% CI: -2.13 to -0.26, P = 0.01]. When the duration of exercise intervention was equal to and greater than 40 min, the effect size was significant [SMD = -1.21, 95% CI: -2.18 to -0.25, P = 0.01]. Meta-regression analysis showed that the P value of the subjects’ BMI (p = 0.009) was < 0.05, and the subjects’ BMI was the main source of heterogeneity. Exercise intervention can increase the concentration of FGF21 in adult plasma, providing a clinical theoretical basis for exercise intervention to regulate FGF21. Currently, there is limited research on exercise intervention, and more research is needed to confirm this theoretical basis due to the complex mechanism of upregulation of FGF21.

KEYWORDS

Exercise, meta-analysis, fibroblast growth factor 21

CITE THIS PAPER

Peilun Li, Jinglin Huang, Exercise Intervention Regulates Fibroblast Growth Factor 21: A Systematic Review and Meta-analysis. MEDS Public Health and Preventive Medicine (2023) Vol. 3: 45-52. DOI: http://dx.doi.org/10.23977/phpm.2023.030107.

REFERENCES

[1] S Pekkala, PK Wiklund, JJ Hulmi, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health. Journal of Physiology-london, 2013, 591(21): 5393-5400.
[2] S Ozbay, S Ulupinar, E Sebin, et al. Acute and chronic effects of aerobic exercise on serum irisin, adropin, and cholesterol levels in the winter season: Indoor training versus outdoor training. Chinese Journal of Physiology, 2020, 63(1): 21-26.
[3] A Zebrowska, M Sikora, A Konarska, et al. Moderate intensity exercise in hypoxia increases IGF-1 bioavailability and serum irisin in individuals with type 1 diabetes. Therapeutic Advances in Endocrinology and Metabolism, 2020, 11.
[4] C Nicolini, B Michalski, SL Toepp, et al. A Single Bout of High -intensity Interval Exercise Increases Corticospinal Excitability, Brain -derived Neurotrophic Factor, and Uncarboxylated Osteolcalcin in Sedentary, Healthy Males. Neuroscience, 2020, 437: 242-255.
[5] K Micielska, JA Kortas, A Gmiat, et al. Habitually inactive physically - a proposed procedure of counteracting cognitive decline in women with diminished insulin sensitivity through a high-intensity circuit training program. Physiology & Behavior, 2021, 229.
[6] PS Rejeki, A Pranoto, RE Prasetya, et al. Irisin serum increasing pattern is higher at moderate-intensity continuous exercise than at moderate-intensity interval exercise in obese females. Comparative Exercise Physiology, 2021, 17(5): 475-484.
[7] K Inoue,S Fujie,N Hasegawa, et al. Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity. Applied Physiology Nutrition and Metabolism, 2020, 45(7): 715-722.
[8] LS Marcucci-Barbosa, FDD Martins, LF Lobo, et al. The effects of strength training session with different types of muscle action on white blood cells counting and Th1/Th2 response. Sport Sciences for Health, 2020, 16(2): 239-248.
[9] E Asghari, SRA Hosseini, M Kiania, et al. The Assessment of Some Metabolic Markers by Combination of Ursolic Acid Supplementation and Resistance Training in Young Older Obese Women. Endocrine Metabolic & Immune Disorders-drug Targets, 2021, 21(10): 1912-1919.
[10] A Saeidi,G Jabbour,M Ahmadian, et al. Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women. Frontiers in Physiology, 2019, 10.
[11] E Banitalebi, A Kazemi, M Faramarzi, et al. Effects of sprint interval or combined aerobic and resistance training on myokines in overweight women with type 2 diabetes: A randomized controlled trial. Life Sciences, 2019, 217: 101-109.
[12] A Ghanbari-Niaki, A Saeidi, M Ahmadian, et al. The combination of exercise training and Zataria multiflora supplementation increase serum irisin levels in postmenopausal women. Integrative Medicine Research, 2018, 7(1): 44-52.
[13] M Kozlowska-Flis, E Rodziewicz-Flis, K Micielska, et al. Short and long-term effects of high-intensity interval training applied alone or with whole-body cryostimulation on glucose homeostasis and myokine levels in overweight to obese subjects. Frontiers in Bioscience-landmark, 2021, 26(11): 1132-1146.
[14] M Sanayei, F Hajizadeh-Sharafabad, R Amirsasan, et al. High-intensity interval training with or without chlorella vulgaris supplementation in obese and overweight women: effects on mitochondrial biogenesis, performance and body composition. British Journal of Nutrition, 2022; 128(2):200-210.
[15] F Scharhag-Rosenberger, T Meyer, M Wegmann, et al. Irisin Does Not Mediate Resistance Training-Induced Alterations in Resting Metabolic Rate. Medicine and Science in Sports and Exercise, 2014, 46(9): 1736-1743.
[16] P Farzanegi, P. Farzanegi. Aerobic and Resistance Exercises Modulate Fibroblast Growth Factor-21 Level in Menopause Women with Type II Diabetes. West Indian Medical Journal, 2022, 69(7): 471-477.
[17] RL Scalzo, GL Peltonen, GR Giordano, et al. Regulators of Human White Adipose Browning: Evidence for Sympathetic Control and Sexual Dimorphic Responses to Sprint Interval Training. Plos One, 2014, 9(3).
[18] F Shabkhiz, M Khalafi, S Rosenkranz, et al. Resistance training attenuates circulating FGF-21 and myostatin and improves insulin resistance in elderly men with and without type 2 diabetes mellitus: A randomised controlled clinical trial. European Journal of Sport Science, 2021, 21(4): 636-645.
[19] R Shabani, F Izaddoust, Ramin Shabani, et al. Effects of aerobic training, resistance training, or both on circulating irisin and myostatin in untrained women. Acta Gymnica, 2018, 48(2): 47-55.
[20] ZW Kong, SY Sun, M Liu, et al. Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women. Journal of Diabetes Research, 2016, 2016.
[21] T Dunnwald, A Melmer, H Gatterer, et al. Supervised Short-term High-intensity Training on Plasma Irisin Concentrations in Type 2 Diabetic Patients. International Journal of Sports Medicine, 2019, 40(3): 158-164.
[22] A Keihanian, H Arazi, M Kargarfard, et al. Effects of aerobic versus resistance training on serum fetuin-A, fetuin-B, and fibroblast growth factor-21 levels in male diabetic patients. Physiology International, 2019, 106(1): 70-80.
[23] A Korkmaz, M Venojarvi, N Wasenius, et al. Plasma irisin is increased following 12 weeks of Nordic walking and associates with glucose homoeostasis in overweight/obese men with impaired glucose regulation. European Journal of Sport Science, 2019, 19(2): 258-266.
[24] H Shirvani, S Rahmati-Ahmadabad, Hossein Shirvani, et al. Irisin interaction with adipose tissue secretions by exercise training and flaxseed oil supplement. Lipids in Health and Disease, 2019, 18.
[25] MAM Zadeh, M Kargarfard, SM Marandi, et al. Diets along with interval training regimes improves inflammatory & anti-inflammatory condition in obesity with type 2 diabetes subjects. Journal of Diabetes and Metabolic Disorders, 2018, 17(2): 253-267.
[26] B Kabak, M Belviranli, N Okudan, et al. Irisin and myostatin responses to acute high-intensity interval exercise in humans. Hormone Molecular Biology and Clinical Investigation, 2018, 35(3).
[27] Eaton Malcolm, Granata Cesare, Barry Julianne. Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle. Journal of Sport and Health Science, 2018, 7(2): 191-196.
[28] LA de Deus, HD Correa, RVP Neves, et al. Metabolic and hormonal responses to chronic blood-flow restricted resistance training in chronic kidney disease: a randomized trial. Applied Physiology Nutrition and Metabolism, 2022, 47(2): 183-194.
[29] D Cordingley, N Turnbull, C Duncan, et al. Higher Concentration Of Irisin In Younger Versus Older Adults Before And Following Blood-flow Restricted Resistance-exercise. Medicine and Science in Sports and Exercise, 2021, 53(8): 101-101.
[30] R Rezaeeshirazi, Reza Rezaeeshirazi. Aerobic Versus Resistance Training: Leptin and Metabolic Parameters Improvement in Type 2 Diabetes Obese Men. Research Quarterly for Exercise and Sport, 2022; 93(3):537-547.
[31] H Shirvani,S Rahmati-Ahmadabad,E Kowsari, et al. Effects of 2-week HMB-FA supplementation with or without eccentric resistance exercise on expression of some genes related to muscle protein turnover and serum irisin and IGF-1 concentrations. Gene, 2020, 760.
[32] A D'Amuri, V Raparelli, JM Sanz, et al. Biological Response of Irisin Induced by Different Types of Exercise in Obese Subjects: A Non-Inferiority Controlled Randomized Study. Biology-basel, 2022, 11(3).
[33] BH Colpitts,BV Rioux,AL Eadie, et al. Irisin response to acute moderate intensity exercise and high intensity interval training in youth of different obesity statuses: A randomized crossover trial. Physiological Reports, 2022, 10(4). 

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 1811
Visits: 84429

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.