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  4. Vol 4, Issue 3, 2023

Current Status and Intervention of Cancer-Induced Fatigue in Patients with Lung Cancer Undergoing Chemotherapy

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DOI: 10.23977/medsc.2023.040309 | Downloads: 22 | Views: 440

Author(s)

Ziyi Li 1,2, Jing Zhao 1,2, Qian Lv 3, Na Zhang 2, Yue Liu 2, Yifang Zhu 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Shaanxi 712046, China
2 Tangdu Hospital, Air Force Military Medical University, Xi'an 710038, China
3 Xi'an Traditional Chinese Medicine Hospital, Xi'an 710021, China

Corresponding Author

Ziyi Li

ABSTRACT

This paper summarized the key issues in the study of cancer-induced fatigue in patients with lung cancer undergoing chemotherapy, and pointed out the main progress in the incidence, evaluation tools, related mechanisms and intervention measures of cancer-induced fatigue in patients with lung cancer undergoing chemotherapy. The intervention strategies for different types of fatigue in patients with lung cancer were discussed. On this basis, the research prospects of cancer-induced fatigue in patients with lung cancer were prospectively discussed.

KEYWORDS

Lung Cancer, Chemotherapy, Cancer-Related Fatigue, Summarization

CITE THIS PAPER

Ziyi Li, Jing Zhao, Qian Lv, Na Zhang, Yue Liu, Yifang Zhu, Current Status and Intervention of Cancer-Induced Fatigue in Patients with Lung Cancer Undergoing Chemotherapy. MEDS Clinical Medicine (2023) Vol. 4: 66-77. DOI: http://dx.doi.org/10.23977/medsc.2023.040309.

REFERENCES

[1] General Office of NHC. (2022) Primary lung cancer diagnosis and treatment guidelines (2022 edition)[J]. Union Medical Journal,13(04):549-570.
[2] Capo, R.D., Gao, Y., Lubin, J.H., et al. (2012) Mood disorders and risk of lung cancer in the eagle case-control study and in the u.s. demographic inpatient cohort. PLo S One, 7(8):e42945.
[3] National Coalition for Cancer Survivorship. (2019) Cancer Survivorship Survey: Findings from an online survey of adult cancer patients. 
[4] Morrow, G.R., Andrews, P.L., Hickok, J.T., Roscoe, J.A. and Matteson, S. (2002) Fatigue associated with cancer and its treatment. Support Care Cancer. Jul; 10(5):389-98.
[5] Effects of pain, fatigue, insomnia, and mood disturbance on functional status and quality of life of elderly patients with cancer. Crit Rev Oncol Hematol. 2011 May; 78(2):127-37.
[6] Ekenga, C.C., Perez, M., Margenthaler, J.A. and Jeffe, D.B. (2018) Early stage Breast cancer and employment participation after 2 years of follow-up: A Comparison with age-matched controls. Cancer. May 1; 124(9):2026-2035.
[7] Bower, J.E. (2014) Cancer-related Fatigue --mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. Oct; 11(10):597-609. 
[8] Yuan, J., Shi, L.L., Wang, Y., Zhu, Y.Z. and Cheng, Y.T. (2021) Effects of chemotherapy on fatigue in elderly patients with non-small cell lung cancer. Huaihai Pharmaceutical, 39(04):361-365.
[9] Song, Y. and Zhi, X.Y. (2021) The correlation between cancer-induced fatigue and hope level in patients with lung cancer undergoing chemotherapy. Cancer Progress, 19(05):525-529.
[10] Leak Bryant, A., Walton, A.L. and Phillips, B. (2015) Cancer-related Fatigue: Scientific Progress has been made in 40 years. Clin J Oncol Nurs. Apr; 19(2):137-9. 
[11] Mendoza, T.R., Wang, X.S., Cleeland, C.S., Johnson, B.A., Wendt, J.K. and Huber, S.L. (1999) Rapid assessment of fatigue severity in cancer patients: Use of The Brief Fatigue Inventory. Mar 1; 85(5):1186-96. 
[12] Lin, C.C., Chang, A.P., Chen, M.L., Cleeland, C.S., Mendoza, T.R. and Wang, X.S. (2006) Validation of Taiwanese Version of the Brief Fatigue Inventory. J Pain Symptom Management. Jul; 32(1):52-9. 
[13] Yellen, S.B., Cella, D.F., Webster, K., Blendowski, C. and Kaplan, E. (1997) Measuring fatigue and other Treasury-related symptoms with the Functional Assessment of Cancer Therapy (FACT) Measurement System. J Pain Symptom Management. Feb; 13(2):63-74. 
[14] Lee, K.A., Hicks, G. and Nino Murcia, G. (1991) Validity and reliability of a scale to assess fatigue. Psychiatry Res. Mar; 36(3):291-8.
[15] Smets, E.M., Garssen, B., Bonke, B. and De Haes, J.C. (1995) The Emotion Inventory (MFI) Psychometric Qualities of an Instrument to assess Fatigue. J Psychosom Res. Apr; 39(3):315-25.
[16] Piper, B.F., Dibble, S.L., Dodd, M.J., Weiss, M.C., Slaughter, R.E. and Paul, S.M. (1998) The Revised Piper Fatigue Scale: Psychometric Evaluation in Women with Breast Cancer. Oncol Nurs Forum. May; 25(4):677-84. 
[17] Zhang, F.L., Ding, Y. and Han, L.S. (2011) Reliability and validity of Chinese version of cancer fatigue scale. Chin J mental health, 25(11):810-813.
[18] Barsevick, A., Frost, M., Zwinderman, A., Hall, P. and Halyard, M; GENEQOL Consortium. (2010) I'm so tired: Biological and genetic mechanisms of cancer-related fatigue. Qual Life Res. Dec; 19(10):1419-27.
[19] Morrow, G.R., Andrews, P.L., Hickok, J.T., Roscoe, J.A. and Matteson, S. (2002) Fatigue associated with cancer and its treatment. Support Care Cancer. Jul; 10(5):389-98.
[20] Li, Y., Yuan, C.R. and Xu, Y. (2008) Related factors and mechanism of cancer-induced fatigue. PLA journal of nursing, 25(9):31-33.
[21] Watkins, L.R., et al. (1994) Neurocircuitry and suppression of illness-induced hyperalgesia. Brain Res, 639:283–299.
[22] Banks, W.A. (2006) The blood-brain barrier in psychoneuroimmunology. Neurol Clin. 24:413–419.
[23] Saligan, L.N., Olson, K., Filler, K., Larkin, D., Cramp, F., Yennurajalingam, S., Escalante, C.P., Del Giglio, A., Kober, K.M., Kamath, J., Palesh, O. and Mustian, K.; First Association of Supportive Care in Cancer Fatigue Study group-biomarker Working Group. (2015) The biology of cancer-related Fatigue: a review of the literature. Support Care Cancer. Aug; 23(8):2461-78. 
[24] Bower, J.E. (2014) Cancer-related Fatigue --mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. Oct; 11(10):597-609.
[25] Kim, S., Miller, B.J., Stefanek, M.E. and Miller, A.H. (2015) Humbly-induced activation of indoleamine 2,3-dioxygenase pathway: Relevance to cancer related fatigue. Jul 1; 121(13):2129-36.
[26] Aggarwal, B.B., Vijayalekshmi, R.V. and Sung, B. (2009) Targeting Pathways for Prevention and therapy of cancer: Short-term friend, long-term foe. Clin Cancer Res. 15:425–430.
[27] Stone, H.B., Coleman, C.N., Anscher, M.S. and McBride, W.H. (2003) Effects of radiation on normal tissue: Consequences and mechanisms. Lancet Oncology. 4:529 -- 536. 
[28] Donovan, K.A., et al. (2004) Course of radiotherapy and/or radiotherapy in women receiving chemotherapy and/or radiotherapy for early stage breast cancer. J Pain Symptom management. 28:373 -- 380.
[29] Zhang, D.P. and Wu, S.J. (2020) Effects of aerobic exercise combined with nursing intervention on fatigue and immune-inflammatory response in patients with lung cancer undergoing chemotherapy.Famous Doctor, (08):248+250.
[30] Wang, X.S., Shi, Q., Williams, L.A., Mao, L., Cleeland, C.S., Komaki, R.R. and Mobley, G.M. (2010) Molecular cytokines are associated with the development of Symptom Burden in patients with NSCLC Undergoing Concurrent chemoradiation therapy. Brain Behav Immun. Aug; 24(6):968-74.
[31] Chou, H.L., Chao, T.Y., Chen, T.C., Chu, C.M., Hsieh, C.H. and Yao, C.T. (2017) The Relationship Between critical Biomarkers and clinical Distress in Lung Cancer Patients Undergoing Chemotherapy. Cancer Nurs. Mar/Apr; 40(2):E1-E8. 
[32] Dhruva, A., Dodd, M., Paul, S.M., et al. (2010) Trajectories of fatigue in patients with breast cancer before, during, and after radiation therapy. Cancer Nurs. 33:201-212. [PubMed: 20357659]
[33] Liu, M., Li, Y. and Liu, X. (2022) Comparative study on the level of Serum tumor necrosis factor-α, Interleukin-1 β, interleukin-6 And interleukin-17 relate to anxiety and depression risks to some extent in non-small cell lung cancer survivor. Clin Respir J. Feb; 16(2):105-115.
[34] O'Higgins, C.M., Brady, B., O'Connor, B., Walsh, D. and Reilly, R.B. (2018) The pathophysiology of cancer related fatigue: a current experiment. Support Care Cancer. Oct; 26(10):3353-3364.
[35] Yang, S., Chu, S., Gao, Y., Ai, Q., Liu, Y., Li, X. and Chen, N. (2019) Pathogenesis of Cancer-related Fatigue (CRF) and Its Possible Pathogenesis. Cells. Jul 18; 8(7):738. 
[36] Shi, J., Yang, H.B., Yang, P., et al. (2022) Effects of integrated medical management intervention on cancer-induced fatigue, lung function and sleep quality in patients with lung cancer undergoing chemotherapy .International Journal of Nursing, 41(15):2840-2844. 
[37] Mustian, K.M., Alfano, C.M., Heckler, C., Kleckner, A.S., Kleckner, I.R., Leach, C.R., Mohr, D., Palesh, O.G., Peppone , L.J., Piper, B.F., Scarpato,  J., Smith, T., Sprod, L.K. and Miller, S.M. (2017) Comparison of Pharmaceutical, Psychological, And The role of Exercise Treatments in cancer-related Fatigue: A meta-analysis. JAMA Oncol. Jul 1; 3(7):961-968.
[38] Nourbakhsh, B., Revirajan, N., Morris, B., Cordano, C., Creasman, J., Manguinao, M., Krysko, K., Rutatangwa, A., Auvray, C., Aljarallah, S., Jin, C., Mowry, E., McCulloch, C. and Waubant, E. (2021) Safety and efficacy of amantadine Methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, double-blind trial. Lancet Neurol. Jan; 20(1):38-48. 
[39] Spathis, A., Fife, K., Blackhall, F., Dutton, S., Bahadori, R., Wharton, R., O'Brien, M., Stone, P., Benepal, T., Bates, N. and Wee, B. (2014) Modafinil for the treatment of Fatigue in lung cancer: Results of a placebo-controlled, double-blind, randomized trial. J Clin Oncol. Jun 20; 32(18):1882-8. 
[40] Gong, S., Sheng, P., Jin, H., He, H., Qi, E., Chen, W., Dong, Y. and Hou, L. (2014) Effect of methylphenidate in patients with cancer-related fatigue: A Systematic Review and meta-analysis. PLoS One, Jan 8; 9(1):e84391.
[41] Wang, X., Zhang, B., Li, J., et al. (2007) Double-blind double-simulated randomized trial of bupropion hydrochloride sustained release tablets in the treatment of depression.Chinese journal of evidence-based medicine, 7(3): 409-414.
[42] Cullum, J.L., Wojciechowski, A.E., Pelletier, G. and Simpson, J.S. (2004) Bupropion sustained release treatment reduces fatigue in cancer patients. Can J Psychiatry. 
[43] Tomlinson, D., Robinson, P.D., Oberoi, S., Cataudella, D., Culos-Reed, N., Davis, H., Duong, N., Gibson, F., Gotte, M., Hinds, P., Nijhof , S.L., Van der Torre, P., Cabral, S., Dupuis, L.L. and Sung, L. (2018) Pharmacologic interventions for fatigue in cancer and transplantation: a meta-analysis. Curr Oncol. Apr; 25(2):e152-e167.
[44] Kelley, G.A. and Kelley, K.S. (2017) Exercise and related fatigue in adults: A systematic review of previous systematic reviews with meta-analyses. BMC Cancer. 
[45] Chen, F., Hu, L.C. and Ye, M.H. (2022) Effect of muscle training combined with aerobic exercise on hypothalamus pituitary adrenal cortex axis in patients with cancer-related fatigue after chemotherapy for lung cancer. Chinese Modern Doctor, 60 (13): 98-101.
[46] Ke, J.F., Chen, S., Chen, S.Y. and Lin, Z.M. (2020) Effect of exercise intervention on cancer induced fatigue and quality of life in patients with lung cancer chemotherapy. J med theory & practice, 33(21):3680-3682.
[47] Yin, Z.M. and Zhang, J.L. (2022) Effects of lung rehabilitation exercise training on lung function, cancer-induced fatigue and quality of life in patients with non-small cell lung cancer undergoing chemotherapy.Journal of Reflexology and Rehabilitation Medicine, 3(7):68-71.
[48] Liu, Y.Y., Lv, L., Li, J., Liu, X.Y. and Du, X. (2022) Effect of graded walking exercise program on cancer-related fatigue of lung cancer patients undergoing chemotherapy. Journal of Bengbu Medical College, 47 (07): 966-970.
[49] Mustian, K.M., Alfano, C.M., Heckler, C., Kleckner, A.S., Kleckner, I.R., Leach, C.R., Mohr, D., Palesh, O.G., Peppone, L.J., Piper, B.F., Scarpato, J., Smith, T., Sprod, L.K. and Miller, S.M. (2017) Comparison of Pharmaceutical, Psychological, And The role of Exercise Treatments in cancer-related Fatigue: A meta-analysis. JAMA Oncol. Jul 1.
[50] Sun, N., Han, P.F. and Liu, D.D. (2021) Study on the application of progressive muscle relaxation training combined with cognitive behavioral intervention in patients with lung cancer undergoing chemotherapy. Chinese Journal of Cancer Clinical and Rehabilitation, 28 (09): 1098-1102.
[51] He, L., Tang, Q., Zhou, F.F., et al. (2019) Effect of nursing intervention based on MBSR on cancer fatigue in patients with lung cancer. Journal of applied clinical nursing, 4(27):36, 40.
[52] Wu, Y.Y. and Liu, Y. (2019) The effects of family coordinated health education on cancer-related fatigue, mental resilience and self-efficacy in patients with lung cancer.Cancer progress, 17(13):1598-1601, 1608. (In Chinese)

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