Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. MEDS Chinese Medicine
  4. Vol 5, Issue 4, 2023

Progress in the Clinical Application of Traditional Chinese Medicine in Treating Hepatic Fibrosis

Download as PDF

DOI: 10.23977/medcm.2023.050415 | Downloads: 10 | Views: 366

Author(s)

Nuannuan Yu 1, Xingwu Yang 2, Chunxia Zhang 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Xingwu Yang

ABSTRACT

Liver fibrosis is a kind of chronic disease process, is a common characteristic of many kinds of chronic liver diseases, If not alleviated and treated as soon as possible, it may deteriorate to cirrhosis or even liver cancer, which seriously reduces the quality of life of patients and endangers their life and health.Western medicine in the treatment of liver fibrosis has not yet clear drugs, but the clinical has proved that traditional Chinese medicine in the treatment of liver fibrosis has a good effect.Through the combination of a variety of traditional Chinese medicine, TCM exerts its multi-target and multi-mechanism therapeutic effect, reduces the side effects of drugs, and has some advantages in the prevention and treatment of liver fibrosis. The TCM dialectics of liver fibrosis are mainly divided into dampness and heat of liver and gallbladder, blockage of blood, Yin deficiency of liver and kidney, liver depression and spleen deficiency. It follows the treatment methods of clearing heat and detoxifying, promoting blood circulation and removing stasis, and fuzheng and tonifying deficiency. The liver fibrosis was delayed and treated by the use of Chinese medicine compound, Chinese medicine monomer, acupuncture, acupoint application, acupoint injection, ear point pressure and other methods. Based on the analysis and summary of the literatures related to liver fibrosis in recent years, this paper summarizes the anti-liver fibrosis of traditional Chinese medicine, in order to provide reference for the clinical treatment of liver fibrosis.

KEYWORDS

Hepatic Fibrosis, Review, TCM, Chinese Medicine Monomer, Chinese Medicine Compound Formula

CITE THIS PAPER

Nuannuan Yu, Xingwu Yang, Chunxia Zhang, Progress in the Clinical Application of Traditional Chinese Medicine in Treating Hepatic Fibrosis. MEDS Chinese Medicine (2023) Vol. 5: 107-113. DOI: http://dx.doi.org/10.23977/medcm.2023.050415.

REFERENCES

[1] Sun T, Zhou Y C, Dang Z B, et al. Professor Hu Shiping's Treatment of chronic hepatitis B liver fibrosis based on Chen Zhixin's idea. Liaoning Journal of Traditional Chinese Medicine: 1-10.
[2] Xiao Z H, Wu L, Chen G L. Chen Guoliang's experience in the diagnosis and treatment of liver fibrosis by Fuzhengdispelling pathogenic factors. Guangming Traditional Chinese Medicine, 2018, 33(07):927-929.
[3] Xu L M. Interpretation of Guidelines for the Diagnosis and Treatment of Hepatic Fibrosis by Integrated Traditional Chinese and Western Medicine (2019 Edition).Shanghai Journal of Traditional Chinese Medicine, 2020, 54(3):29-31, 52. 
[4] Qian P G. Correlation study between TCM syndrome type and clinical index of liver fibrosis. Shanxi University of Traditional Chinese Medicine, 2017.
[5] Zhou X, Gu D, Tong C, et al. Effect of Bijiajian Pills on liver fibrosis induced by CCl_4 in mice. Shaanxi Journal of Traditional Chinese Medicine, 202, 43(02):151-156.
[6] Zhang L Y, Tao C H, Xuan C, et al. Yiqi Huayu Ruogan Formula alleviates CCl_4-induced hepatic fibrosis in rats by regulating the activity of NLRP3 inflammasome. Journal of Immunology, 201, 37(10):829-836+853.
[7] Wu S F, Zhao X P, Zhang J, et al. Effects of Entecavir combined with Compound Biejiruangan Tablets on serum liver fibrosis and hepatitis B virus related indexes in patients with hepatitis B cirrhosis during compensatory stage. Chinese Journal of Medicine and Clinical Medicine, 2002, 22(03):269-272.
[8] Xin X, CAI B Y, Chen C, et al. Effect of Fuzheng Huayu Capsule on mice with nonalcoholic fatty liver fibrosis. Chinese Journal of Experimental Formulae, 201, 27(06):37-45.
[9] Cao R, Zhu Y Q, Lin H M, et al. Rhubarb Zhezhu Pills regulate ASIC1a/VEGF pathway to relieve liver fibrosis. Chinese Journal of Pharmacology, 2002, 38(06):928-934.
[10] Xiao Z H, Yang H, Yang J, et al. Effect of Fugan Huaxian Decoction on MAPK signaling pathway in hepatic fibrosis model rats. Chinese Journal of Herbal Medicine, 2019, 50(14):3374-3381.
[11] Chao L Q, Wang F. Effect of Jianwei Sini Powder on liver fibrosis in rats. Journal of Integrated Traditional and Western Medicine Hepatology, 201, 31(04):352-355. (in Chinese)
[12] Chen T T. Study on the mechanism of Guizhi Poria Pills in treating hepatic fibrosis based on TGF-β1/Smad2 signaling pathway. Tutor: Gao Yongxiang. Chengdu University of Traditional Chinese Medicine, 2021.
[13] Zhou L H, Chen X. Gardeniin inhibits hepatic fibrosis and hepatic stellate cell activation through TGF-β1/Smad signaling pathway. Acta Physiologica Sinica, 2002, 74(02):217-224.
[14] Huang Y, Xia L, Lei Q S, et al. Protective effect of saikosaponin D on immune hepatic fibrosis in rats. Journal of Army Medical University, 202, 44(14):1410-1420.
[15] Lei L, Min J, Liu F, et al. Study on the protective effect and mechanism of Astragalus on liver injury in rats with liver fibrosis. Shaanxi Journal of Traditional Chinese Medicine, 20, 41(09):1192-1196.
[16] Chen W L, Dai F Z, Shao Z Y, et al. Inhibition and protection of quercetin on hepatic fibrosis induced by carbon tetrachloride in rats. Chinese Journal of Immunology, 201, 37(01):46-50.
[17] Zheng Y, Lu N Y, Huang Y X, et al. Effects of curcuma curcumin on hepatic fibrosis in mice based on TGF-β1/Smad signaling pathway. Chinese Journal of Traditional Chinese Medicine, 201, 39(11):149-152+271-272.
[18] Sun Y. Effects of arbutin on hepatic fibrosis and its mechanism. Supervisor: Guo Jiao. (in Chinese) Guangdong Pharmaceutical University, 2019.
[19] Wang Z Y, Wang X, Zhang Z Y, et al. Inhibitory effect of artesunate on hepatic stellate cell activation through iron death pathway. Chinese Journal of Traditional Chinese Medicine, 2022, 37(01):455-460.
[20] Luo Q, Li S J, Liu W J, et al. Effect of electroacupuncture and natural moxibustion on mast cells at Ganshu Point in rats with hepatic fibrosis. Clinical Journal of Acupuncture and Moxibustion, 2015, 31(04): 59-63+91.
[21] Deng Z W, Guan X L, Zhang S P.A randomized parallel control study of Xiangdan Injection combined with diammonium glycyrrhizinate in treatment of chronic hepatitis B. Journal of Practical TCM Internal Medicine, 2017, 31(10): 82-85.
[22] Gao H, Hui T. Clinical study of Buganshen paste prescription combined with glycyrrhizin diamine enteric-coated capsule in treating Hepatitis B liver fibrosis. Shaanxi Traditional Chinese Medicine, 2018, 39(12):1719-1721.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 4191
Visits: 164500

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.