Education, Science, Technology, Innovation and Life
Open Access
Sign In

Matrix Stiffness Regulation of Macrophage Function

Download as PDF

DOI: 10.23977/medsc.2023.040312 | Downloads: 15 | Views: 444

Author(s)

Yan Wang 1,2, Wang Huiqin 1, Li Jing 2, Song Liqiang 2

Affiliation(s)

1 The Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, 712000, China
2 Department of Respiratory and Critical Care Medicine, Xijing Hospital, Air Force Medical University, Xi'an, 710000, China

Corresponding Author

Song Liqiang

ABSTRACT

Macrophages are found throughout the body, engulfing microorganisms and cell debris, while coordinating inflammatory responses to maintain tissue homeostasis. As macrophages patrol within different organs and tissues, they are exposed not only to a variety of biochemical cues, but also to mechanical cues, such as tissue stiffness. More and more studies have shown that macrophages can sense changes in microenvironment stiffness, but little is known about the molecular mechanism of how stiffness regulates macrophage function. The 2020 Nobel Prize-winning mechanically-sensitive ion channels the transient receptor potential channel subfamily V member 4 (TRPV4) and Piezo1 are of widespread interest. Research suggests that Piezo1 and TRPV4 on macrophages can sense matrix stiffness in the microenvironment and convert it into biochemical signals to activate specific cellular effector functions. These findings help us better understand how microenvironment stiffness affects macrophage behavior, which may be associated with diseases in which tissue stiffness is altered, and may enhance our understanding of disease mechanisms.

KEYWORDS

Macrophage; Stiffness; TRPV4; Piezo1

CITE THIS PAPER

Yan Wang, Wang Huiqin, Li Jing, Song Liqiang, Matrix Stiffness Regulation of Macrophage Function. MEDS Clinical Medicine (2023) Vol. 4: 94-100. DOI: http://dx.doi.org/10.23977/medsc.2023.040312.

REFERENCES

[1] Gentek R, Molawi K, Sieweke M H. Tissue macrophage identity and self-renewal[J]. Immunol Rev, 2014,262(1):56-73.
[2] Orsini E M, Perelas A, Southern B D, et al. Stretching the Function of Innate Immune Cells[J]. Front Immunol, 2021, 12: 767319.
[3] Nia H T, Munn L L, Jain R K. Physical traits of cancer[J]. Science, 2020,370(6516).
[4] Theocharis A D, Skandalis S S, Gialeli C, et al. Extracellular matrix structure [J]. Adv Drug Deliv Rev, 2016,97:4-27.
[5] Bunevicius A, Schregel K, Sinkus R, et al. REVIEW: MR elastography of brain tumors [J]. Neuroimage Clin, 2020, 25: 102109.
[6] Miroshnikova Y A, Mouw J K, Barnes J M, et al. Tissue mechanics promote IDH1-dependent HIF1alpha-tenascin C feedback to regulate glioblastoma aggression [J]. Nat Cell Biol, 2016,18(12):1336-1345.
[7] Tao B, Song Y, Wu Y, et al. Matrix stiffness promotes glioma cell stemness by activating BCL9L/Wnt/beta-catenin signaling [J]. Aging (Albany Ny), 2021,13(4):5284-5296.
[8] Booth A J, Hadley R, Cornett A M, et al. Acellular normal and fibrotic human lung matrices as a culture system for in vitro investigation[J]. Am J Respir Crit Care Med, 2012,186(9):866-876.
[9] Venkatesh S K, Yin M, Glockner J F, et al. MR elastography of liver tumors: preliminary results[J]. Ajr Am J Roentgenol, 2008,190(6):1534-1540.
[10] Du H, Bartleson J M, Butenko S, et al. Tuning immunity through tissue mechanotransduction[J]. Nat Rev Immunol, 2023, 23(3):174-188.
[11] Thurner P J. Atomic force microscopy and indentation force measurement of bone[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2009,1(6):624-649.
[12] Kashif A S, Lotz T F, McGarry M D, et al. Silicone breast phantoms for elastographic imaging evaluation[J]. Med Phys, 2013, 40(6):63503.
[13] Plodinec M, Loparic M, Monnier C A, et al. The nanomechanical signature of breast cancer[J]. Nat Nanotechnol, 2012, 7(11):757-765.
[14] Cao H, Duan L, Zhang Y, et al. Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity[J]. Signal Transduct Target Ther, 2021, 6(1):426.
[15] Gu L, Mooney D J. Biomaterials and emerging anticancer therapeutics: engineering the microenvironment[J]. Nat Rev Cancer, 2016, 16(1):56-66.
[16] Pradhan S, Hassani I, Clary J M, et al. Polymeric Biomaterials for In Vitro Cancer Tissue Engineering and Drug Testing Applications [J]. Tissue Eng Part B Rev, 2016,22(6):470-484.
[17] Roudsari L C, West J L. Studying the influence of angiogenesis in in vitro cancer model systems[J]. Adv Drug Deliv Rev, 2016, 97:250-259.
[18] McGrail D J, Kieu Q M, Dawson M R. The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway[J]. J Cell Sci, 2014,127(Pt 12):2621-2626.
[19] Guiro K, Patel S A, Greco S J, et al. Investigating breast cancer cell behavior using tissue engineering scaffolds[J]. Plos One, 2015, 10(3):e118724.
[20] Pradhan S, Hassani I, Seeto W J, et al. PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture[J]. J Biomed Mater Res a, 2017, 105(1):236-252.
[21] Hsieh J Y, Keating M T, Smith T D, et al. Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation [J]. Apl Bioeng, 2019, 3(1):16103.
[22] Blakney A K, Swartzlander M D, Bryant S J. The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)-based hydrogels[J]. J Biomed Mater Res a, 2012, 100(6): 1375-1386.
[23] Adlerz K M, Aranda-Espinoza H, Hayenga H N. Substrate elasticity regulates the behavior of human monocyte-derived macrophages[J]. Eur Biophys J, 2016,45(4):301-309.
[24] Gruber E, Heyward C, Cameron J, et al. Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)[J]. Int Immunol, 2018,30(6):267-278.
[25] Previtera M L, Sengupta A. Substrate Stiffness Regulates Proinflammatory Mediator Production through TLR4 Activity in Macrophages [J]. Plos One, 2015,10(12):e145813.
[26] Sridharan R, Cavanagh B, Cameron A R, et al. Material stiffness influences the polarization state, function and migration mode of macrophages[J]. Acta Biomater, 2019,89:47-59.
[27] Escolano J C, Taubenberger A V, Abuhattum S, et al. Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response[J]. Front Cell Dev Biol, 2021,9:639815.
[28] Carnicer-Lombarte A, Barone D G, Dimov I B, et al. Mechanical matching of implant to host minimises foreign body reaction [J]. Biorxiv, 2019:829648.
[29] Xing X, Wang Y, Zhang X, et al. Matrix stiffness-mediated effects on macrophages polarization and their LOXL2 expression [J]. Febs J, 2021, 288(11):3465-3477.
[30] Irwin E F, Saha K, Rosenbluth M, et al. Modulus-dependent macrophage adhesion and behavior[J]. J Biomater Sci Polym Ed, 2008, 19(10):1363-1382.
[31] Strotmann R, Harteneck C, Nunnenmacher K, et al. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity[J]. Nat Cell Biol, 2000,2(10):695-702.
[32] Liedtke W, Choe Y, Marti-Renom M A, et al. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor[J]. Cell, 2000,103(3):525-535.
[33] Clapham D E, Runnels L W, Strubing C. The TRP ion channel family[J]. Nat Rev Neurosci, 2001,2(6):387-396.
[34] Vig M, Kinet J P. Calcium signaling in immune cells[J]. Nat Immunol, 2009, 10(1):21-27.
[35] Santoni G, Morelli M B, Amantini C, et al. "Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses[J]. Front Immunol, 2018,9:1273.
[36] Michalick L, Kuebler W M. TRPV4-A Missing Link Between Mechanosensation and Immunity[J]. Front Immunol, 2020,11:413.
[37] Scheraga R G, Abraham S, Niese K A, et al. TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis[J]. J Immunol, 2016,196(1):428-436.
[38] Scheraga R G, Abraham S, Grove L M, et al. TRPV4 Protects the Lung from Bacterial Pneumonia via MAPK Molecular Pathway Switching [J]. J Immunol, 2020,204(5):1310-1321.
[39] Dutta B, Goswami R, Rahaman S O. TRPV4 Plays a Role in Matrix Stiffness-Induced Macrophage Polarization[J]. Front Immunol, 2020,11:570195.
[40] Coste B, Mathur J, Schmidt M, et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels [J]. Science, 2010,330(6000):55-60.
[41] Zhao Q, Zhou H, Chi S, et al. Structure and mechanogating mechanism of the Piezo1 channel[J]. Nature, 2018, 554(7693):487-492.
[42] Lai A, Cox C D, Chandra S N, et al. Mechanosensing by Piezo1 and its implications for physiology and various pathologies[J]. Biol Rev Camb Philos Soc, 2022,97(2):604-614.
[43] Atcha H, Jairaman A, Holt J R, et al. Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing [J]. Nat Commun, 2021,12(1):3256.
[44] Atcha H, Meli V S, Davis C T, et al. Crosstalk Between CD11b and Piezo1 Mediates Macrophage Responses to Mechanical Cues [J]. Front Immunol, 2021,12:689397.
[45] Baratchi S, Zaldivia M, Wallert M, et al. Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress-Induced, Piezo-1-Mediated Monocyte Activation[J]. Circulation, 2020, 142(11): 1092- 1105.
[46] Solis A G, Bielecki P, Steach H R, et al. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity [J]. Nature, 2019,573(7772):69-74.
[47] Tang Z, Wei X, Li T, et al. Three-Dimensionally Printed Ti2448 With Low Stiffness Enhanced Angiogenesis and Osteogenesis by Regulating Macrophage Polarization via Piezo1/YAP Signaling Axis[J]. Front Cell Dev Biol, 2021,9:750948.
[48] Geng J, Shi Y, Zhang J, et al. TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection[J]. Nat Commun, 2021,12(1):3519.
[49] Meli V S, Veerasubramanian P K, Atcha H, et al. Biophysical regulation of macrophages in health and disease[J]. J Leukoc Biol, 2019,106(2):283-299.
[50] Huang S, Ingber D E. Cell tension, matrix mechanics, and cancer development[J]. Cancer Cell, 2005,8(3):175-176.
[51] Stewart G M, Johnson B D, Sprecher D L, et al. Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial[J]. Eur J Heart Fail, 2020,22(9):1641-1645.
[52] Mole S, Harry A, Fowler A, et al. Investigating the effect of TRPV4 inhibition on pulmonary-vascular barrier permeability following segmental endotoxin challenge[J]. Pulm Pharmacol Ther, 2020,64:101977.
[53] Ludbrook V J, Hanrott K E, Kreindler J L, et al. Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough [J]. Erj Open Res, 2021, 7(3).

Downloads: 4166
Visits: 181208

Sponsors, Associates, and Links


All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.