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  4. Vol 4, Issue 1, 2023

Molecular Regulation Mechanisms of Ferroptosis and Its Progress in AML Treatment

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DOI: 10.23977/tranc.2023.040109 | Downloads: 12 | Views: 387

Author(s)

Rong Wang 1, Zhihui Zhou 2, Naichuan Chen 1, Zihui Li 1, Hong Li 1,3

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China
3 Pharmaceutical Factory, Shaanxi University of Chinese Medicine, Xianyang, 712083, China

Corresponding Author

Hong Li

ABSTRACT

This review focuses on the intricate molecular mechanisms and advancements of ferroptosis in Acute Myeloid Leukemia (AML) treatment. AML, an uncontrolled proliferation of undifferentiated myeloid precursor cells, demonstrates a high degree of chemotherapy resistance, resulting in poor prognosis. Ferroptosis, a distinct form of cell death involving iron accumulation and lipid peroxidation, has emerged as a promising therapeutic strategy. Herein, we dissect the oxidative-antioxidative mechanisms and iron death, highlighting the roles of the glutathione system and Fenton reaction. Furthermore, the association of lipid peroxidation with ferroptosis, as well as the advancements in AML research focusing on the XCT-GSH-GPX4 pathway and the interplay of autophagy and ferroptosis, are detailed. This comprehensive analysis underscores the potential of ferroptosis as a targeted therapeutic approach for AML.

KEYWORDS

Ferroptosis, Acute Myeloid Leukemia, Oxidative-Antioxidative Mechanisms, XCT-GSH-GPX4 Pathway, Autophagy

CITE THIS PAPER

Rong Wang, Zhihui Zhou, Naichuan Chen, Zihui Li, Hong Li, Molecular Regulation Mechanisms of Ferroptosis and Its Progress in AML Treatment. Transactions on Cancer (2023) Vol. 4: 60-64. DOI: http://dx.doi.org/10.23977/tranc.2023.040109.

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