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  4. Vol 5, Issue 8, 2023

Research Progress of Traditional Chinese Medicine in Treating IgA Nephropathy through Notch Signaling Pathway

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DOI: 10.23977/medcm.2023.050801 | Downloads: 15 | Views: 391

Author(s)

Mei Chen 1, Jian Shi 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, Shaanxi, 710003, China

Corresponding Author

Jian Shi

ABSTRACT

IgA nephropathy is one of the most common primary glomerular diseases, with a high incidence and varying clinical manifestations. The Notch pathway is an important cell signaling pathway that regulates cell differentiation, proliferation, development and apoptosis, and plays a key role in many developmental processes, including kidney development. A number of experimental studies have confirmed that the Notch signaling pathway is closely related to IgA nephropathy and is an important pathway involved in the pathogenesis of IgA nephropathy. In recent years, with the study of the active ingredients of traditional Chinese medicine(TCM), a large number of experimental and clinical studies have confirmed that TCM has unique advantages and curative effects in preventing and treating IgA nephropathy. Since there are relatively few studies on the use of TCM in the treatment of IgA nephropathy related to the Notch pathway, this article mainly introduces the related mechanism research of Notch signaling pathway involved in IgA nephropathy, and summarizes the relevant research on the regulation of Notch signaling pathway and anti-fibrosis of Chinese medicine ingredients in IgA nephropathy.

KEYWORDS

Traditional Chinese medicine; IgA nephropathy; Intervention; Notch signaling pathway; Renal fibrosis

CITE THIS PAPER

Mei Chen, Jian Shi, Research Progress of Traditional Chinese Medicine in Treating IgA Nephropathy through Notch Signaling Pathway. MEDS Chinese Medicine (2023) Vol. 5: 1-8. DOI: http://dx.doi.org/10.23977/medcm.2023.050801.

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