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  4. Vol 5, Issue 8, 2023

Exploration on the Mechanisms of Chinese Herbal Medicine (Golden Thread) for Tuberculosis based on the Focused Network Pharmacology

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DOI: 10.23977/medcm.2023.050803 | Downloads: 15 | Views: 405

Author(s)

Jing Liu 1, Hongyu Fang 1, Qiumei Duan 1, Ying Luo 1, Wenqian Zhang 1, Fan Li 2

Affiliation(s)

1 Xi'an Jiaotong University City College, Xi'an, Shaanxi, 710018, China
2 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Corresponding Author

Jing Liu

ABSTRACT

In order to explore the active ingredient, potential targets, and the tuberculosis-related molecular mechanism of Golden thread along with the scientific explanations based on the method of network pharmacology. We retrieved the active components and the targets of the Golden thread from the TCMSP database. The target genes corresponding to tuberculosis were screened and obtained from GeneCards and OMIM, and the disease-drug protein target genes were obtained after the intersection of the two. The target network of Golden thread's active ingredient for tuberculosis was constructed using Cytoscape. String database was used for the protein-protein interaction analysis.Resultly, a total of 48 corresponding components of Golden thread were searched in the TCMSP database and screened, which revealed 14 active components having good interactions with 75 TB-related target proteins. The network pharmacology analysis revealed that the biological functions of the Golden thread–TB intersection target genes mainly included immune response, signal transduction, metabolism, and the regulation of the tumor necrosis factor signaling pathways, IL-17 and Toll-like receptors signaling pathways, HIF-1 signaling pathway, and tuberculosis-related pathways to play a role in the intervention of TB. To sum up, the present work explored the different active ingredients of Golden thread playing a role in the intervention of TB and the role of multiple pathway characteristics, and performed a preliminary validation of the basic pharmacological effects of Golden thread and their underlying mechanism, providing novel insights into the mechanism of action of Golden thread intervention in TB. 

KEYWORDS

Network pharmacology; Golden thread; Bioinformatics; Tuberculosis; Analysis

CITE THIS PAPER

Jing Liu, Hongyu Fang, Qiumei Duan, Ying Luo, Wenqian Zhang, Fan Li, Exploration on the Mechanisms of Chinese Herbal Medicine (Golden Thread) for Tuberculosis based on the Focused Network Pharmacology. MEDS Chinese Medicine (2023) Vol. 5: 16-25. DOI: http://dx.doi.org/10.23977/medcm.2023.050803.

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