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  4. Vol 4, Issue 6, 2023

Ferroptosis: Emerging mechanisms, biology and hallmarks

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DOI: 10.23977/medsc.2023.040608 | Downloads: 10 | Views: 265

Author(s)

Zixun Wang 1, Daowei Li 1

Affiliation(s)

1 Jilin Provincial Key Laboratory of Oral Biomedical Engineering, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China

Corresponding Author

Daowei Li

ABSTRACT

Ferroptosis is a new type of cell death which is iron-dependent and caused by lipid peroxidation, distinguished from apoptosis, necrosis, pyroptosis, and autophagy. The occurrence of ferroptosis is determined by the balance between the ferroptosis execution systems and the ferroptosis defense systems. The ferroptosis execution system includes iron metabolism, lipid metabolism, mitochondrial metabolism, etc., which induces ferroptosis by promoting the production of ROS. The ferroptosis resistance system is mainly comprised of antioxidants such as GPX4 and coenzyme Q (CoQ), which eleminate ROS and suppress ferroptosis. After cells undergo ferroptosis, morphological, biochemical, genetic, immune, and other changes occur. This review focuses on the molecular mechanism and characteristics of ferroptosis, and analyzes the potential problems as well as directions of its future research.

KEYWORDS

Ferroptosis, cell death, lipid peroxidation, iron metabolism

CITE THIS PAPER

Zixun Wang, Daowei Li, Ferroptosis: Emerging mechanisms, biology and hallmarks. MEDS Clinical Medicine (2023) Vol. 4: 51-60. DOI: http://dx.doi.org/10.23977/medsc.2023.040608.

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