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Research Progress on Recognition and Treatment of RSV Infection in Traditional Chinese Medicine

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DOI: 10.23977/medcm.2023.050903 | Downloads: 7 | Views: 279

Author(s)

Xinyu Wang 1, Guocheng Zhang 2, Yuqi Hao 1

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China

Corresponding Author

Guocheng Zhang

ABSTRACT

Respiratory syncytial virus (RSV) is the main cause of bronchiolitis and pneumonia in infants, the elderly and immunocompromised people worldwide. At present, there are no antiviral drugs and vaccines suitable for clinical use. In view of RSV infection, Chinese medicine has the advantages of less toxic and side effects and excellent therapeutic effect. Chinese scholars have carried out a lot of clinical observation and basic research, and found many single Chinese medicine and Chinese medicine compounds with remarkable curative effects. The results of clinical research show that Chinese medicine can relieve symptoms such as asthma, cough and sputum secretion. Basic research has found that the mechanism of anti-RSV infection of traditional Chinese medicine focuses on preventing virus replication and reducing the release of pro-inflammatory mediators. This paper reviews the related contents in order to provide theoretical basis for the study of traditional Chinese medicine against RSV infection.

KEYWORDS

Traditional Chinese medicine and pharmacy, Respiratory syncytial virus, Research progress, Fundamental research, Clinical research

CITE THIS PAPER

Xinyu Wang, Guocheng Zhang, Yuqi Hao, Research Progress on Recognition and Treatment of RSV Infection in Traditional Chinese Medicine. MEDS Chinese Medicine (2023) Vol. 5: 18-26. DOI: http://dx.doi.org/10.23977/medcm.2023.050903.

REFERENCES

[1] Chen Wenxia, Yan Yongbin, Fan Shuhua. Analysis of syndrome differentiation and treatment of children with bronchiolitis obliterans [J]. Traditional Chinese Medicinal Research, 2016, 29(09): 7-9. 
[2] Qin Likui, Zhang Fengxue, Huang Xiaojuan, Song Hong, Gong Wenliang. Study on the Effect of Yinqiao Powder on the Respiratory System of Mice Infected with Respiratory Syncytial Virus [J]. New Chinese Medicine, 2018, 50(05): 24-30. DOI: 10. 13457/j. cnki. jncm. 2018. 05. 006. 
[3] Wang Xuefeng, Wang Siyuan, Yue Zhijun, et al. Study on the expression of inflammatory cytokines and the regulation of TLR-4/NF-κB signaling pathway in mice with RSV-induced pneumonia by three treatments[J]. Liaoning Journal of Traditional Chinese Medicine, 2014, 41(03): 385-387. DOI: 10. 13192/j. issn. 1000-1719. 2014. 03. 001. 
[4] Zhu Wanqing. Experimental study on the effect of double table method on TNF-α and IFN-γ in mouse pneumonia induced by RSV [D]. Liaoning University of Traditional Chinese Medicine, 2013. 
[5] Wang Siyuan, Bo Han, Nan Chunhong, etal. Effects of Maxing Shigan decoction on lung inflammatory response of asthmatic mice inducted by RSV [J]. Shandong Medical Journal. 2020, 60(01):48-51. 
[6] Wang Weiqun, Shao Zhengyang, Xu Xianke, et al. Effects of Jia Wei Ma Xing Shi Gan Decoction on serum TNF-α, ECP and lung pathology in rats infected by respiratory syncytlal virus. [J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2012, 22(06):420-423. 
[7] Li Mengwen. Study on mechanism of Ma Xing Shi Gan Decoction (MXSGD) in intervention of asthma airway inflammation and itscompatibility [D]. Nanjing University of Traditional Chinese Medicine, 2021. DOI: 10. 27253/d. cnki. gnjzu. 2021. 000057. 
[8] Cui Zhenze, Huang Yan, Xu Chao. Effect of Dingchuan decoction on the inflammatory cells in BALF of young rats infected with RSV [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2017, 9(05):369-371+461. 
[9] Ou Yangzhen, Chi Lei, Xu Chao, etal. Liquid chromatography-mass spectrometry-based metabolomics study of the efficacy of Chinese medicine asthma-relieving decoction on respiratory syncytial virus infection [J]. Chinese Journal of Chromatography, 2021, 39(03):281-290. 
[10] Huang Yan, Xu Chao, Cui Zhenze. Immunoregulatory effects of asthma - relieving decoction and its decomposed potion in rats with respiratory syncytial virus [J]. Lishizhen Medicine and Materia Medica Research, 2016, 27(09): 2078-2081. 
[11] Huang Yan, Xu Chao, Cui Zhenze, et al. Study on influence of Dingchuan Decoction on balance factors of immune network in respiratory syncytial virus (RSV) infected rats [J]. Journal of Pediatrics of Traditional Chinese Medicine, 2018, 14(02):10-15. DOI:10. 16840/j. issn1673-4297. 2018. 02. 03. 
[12] Cui Zhenze, Huang Yan, Liu mingtao, et al. Effects of Asthma-relieving Decoction on expression of TSLP and GATA3 in lung tissue of rats with respiratory syncytial virus infection [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2018, 33(12):5581-5583. 
[13] Wei Xiangyu. Clinical observation of Yuxingcao atomization combined with montelukast in treating respiratory syncytial virus pneumonia [D]. Guangzhou University of Traditional Chinese Medicine, 2017. 
[14] Zhang Wenfeng, Hu Fengren, Peng Kangda, et al. Clinical Analysis of Qingfei Jiedu Method in the Treatment of Children withRespiratory Syncytial Virus Pneumonia [J]. Modern Diagnosis and Treatment, 2017, 28(06):994-995. 
[15] Mo Yaoding. Efficacy of Traditional Chinese Medicine in Treating Children's Respiratory Syncytial Virus Pneumonia [J]. Inner Mongolia Journal of Traditional Chinese Medicine, 2019, 38(04): 27-28. DOI: 10. 16040/j. cnki. cn 15-1101. 2019. 04. 020. 
[16] Yuan Bin, Sun Yiqiu, Ren Huijie, et al. Clinical Study on Qingfei Oral Liquid in Treating Children with RSV Pneumonia Syndrome of Phlegm-heat Closing the Lung [J]. Jiangsu Journal of Traditional Chinese Medicine, 2008, 40(12): 36-37. 
[17] Pan Yueting, Zhu Liang. Effects of traditional Chinese medicine chrysanthemum decoction on Pediatric RSV infection after A549 cell chemotactic factor [J]. Chinese Journal of Biochemical and Pharmaceuticals, 2015, 35(03): 82-84. 
[18] Tong Dan, Hong Yan, Chen Yuan, et al. Effects of Qingfei Pingchuan decoction on the tidal breathing lung function in children with respiratory syncytial virus pneumonia (phlegm-heat closing lung) [J]. Chinese Pediatrics of Integrated Traditional and Western Medicine, 2018, 10(05):413-417. 
[19] Tong Dan, Hong Yan, Zhan Ning, et al. Effect of Clearing Lung - Heat and RelievePanting Decoction on Eotaxin and IL-17in Children with Respiratory Syncytial Virus Pneumonia [J]. Journal of Shaanxi University of Chinese Medicine, 2019, 42(01):115-118. DOI:10. 13424/j. cnki. jsctcm. 2019. 01. 035. 
[20] Cheng Shen, Li Lan, Wang Liling, et al. Clinical Observation on Maozhi Decoction in the Treatment of Respiratory Syncytial Virus Infected Bronchiolitis in Children [J]. Zhejiang Journal of Integrated Traditional Chinese and Western Medicine, 2022, 32(07):637-639. 
[21] Zhou Yongmao, He Degen, Wang Xinfang. Curative effect observation of combination of TCM and western medicine intreating children with respiratory tract infection [J]. Clinical Journal of Chinese Medicine, 2016, 8(15): 92-93. 
[22] He Yahui, Jiang Chunying, Liu Xiaolin, etal. Observation on the Efficacy of Traditional Chinese Medicine Kudiezi against Respiratory Virus [J]. Chinese Journal of Public Health, 2006(08):980-981. 
[23] Shi Chenxiao. Study on Isolation and Purification of the Effective Anti-Respiratory Syncytial Virusfrom Euonymus alatus (Thunb.) Sieb andits Anti-viral Mechanism [D]. Shandong University of Traditional Chinese Medicine, 2020. DOI: 10. 27282/d. cnki. gsdzu. 2020. 000478. 
[24] Wang Tianqing, Zhang Ying, Jiang Hong, etal. Effect of Belamcanda Chinensison Airway Inflammation in Guinea Pigswith Respiratory Syncytial Virus Infection [J]. Chinese Archives of Traditional Chinese Medicine, 2019, 37(09): 2128-2132+2313. DOI:10. 13193/j. issn. 1673-7717. 2019. 09. 019. 
[25] Wang Jifeng. Extraction and Separation of Polysaccharidesfrom Common Sage Herb and Study onAnti-Respiratory Syncytial Virus [D]. Shandong University of Traditional Chinese Medicine, 2019. DOI:10. 27282/d. cnki. gsdzu. 2019. 000959. 
[26] Cui Zhenzhen. Study on Isolation and Purification of the EffectiveAnti Respiratory Syncytial Virus from Hibiscusmutabilis Leaf and its Anti-viral Mechanism [D]. Shandong University of Traditional Chinese Medicine, 2019. DOI: 10. 27282/d. cnki. gsdzu. 2019. 000118. 
[27] Xu jiaxin. Study on the Effect Parts of Methahaplocalyx against Respiratory Syncytial Virus [D]. Shandong University of Traditional Chinese Medicine, 2019. DOI: 10. 27282/d. cnki. gsdzu. 2019. 000955. 
[28] Yan Weiwei. Isolation of Active Fractions from HolotrichiaeLarva and Pulsatilla Chinenais (Bge.) Regeland Study on Antiviral Mechanism of their Compatibility [D]. Shandong University of Traditional Chinese Medicine, 2019. DOI: 10. 27282/d. cnki. gsdzu. 2019. 000970. 
[29] Qin Sheng. The Inhibitory Effect and Mechanism of Baicalin on Respiratory Syncytial Virus Infection [D]. Southern Medical University, 2022. DOI:10. 27003/d. cnki. gojyu. 2022. 000200. 
[30] Shi Hengfei. Baicalin is a naturally occurring flavone that efficientlyinhibits RSV replication [D]. Nanjing University, 2016. 
[31] Hu Xiaoyuan, Yin Feifei, Zhang Junqing, et al. In Vitro Study on the Antiviral Activity of 9 Extracts of Traditional Chinese Herbal Medicine Against the Human Respiratory Syncytial Virus [J]. Journal of Hainan Medical University, 2022, 28(21):1601-1607. DOI:10. 13210/j. cnki. jhmu. 20220705. 001. 
[32] Liu Chunyuan. Study on the Inhibitory Effect and Mechanism ofFive Sophora flavescens Alkaloids on Human Respiratory Syncytial Virus in Vitro [D]. Guizhou Medical University, 2021. DOI: 10. 27045/d. cnki. ggyyc. 2021. 000027. 
[33] Zhu Xiuzhen, Shen Wenwei, Gong Cuiying, etal. Antiviral Activity of Isoorientin against Respiratory Syncytial Virus in Vitro and in Vivo [J]. Journal of Sun Yat-sen University (Medical Sciences), 2015, 36(03):352-359. DOI: 10. 13471/j. cnki. j. sun. yat-sen. univ(med. sci). 2015. 0057. 
[34] Bao Yanyan, Gao Yingjie, Zhou Lili, et al. The efficacy of compound Qinlan oral liquid on respiratory virus infection [J]. World Chinese Medicine, 2021, 16(12):1809-1817. 
[35] Ling Xiaoying. Mechanism of Qingfei Oral Liquid flavonoids intreating RSV pneumonia by regulating necroptosis [D]. Nanjing University of Traditional Chinese Medicine, 2022. DOI:10. 27253/d. cnki. gnjzu. 2022. 000123. 
[36] Li Xixuan. Study on the anti RSV mechanism of flavonoids in Qingfei oral liquid based on NF- k B signaling pathway [D]. Nanjing University of Traditional Chinese Medicine, 2021. DOI:10. 27253/d. cnki. gnjzu. 2021. 000425. 
[37] An Li. Professor Wang Shouchuan's Experience in Treating Pediatric Viral Pneumonia Based on Theories of 'Heat Depression with Phlegm and Stasis'and Research on the Metabolic and Immune Mechanism of Qingfei Oral Liquid [D]. Nanjing University of Traditional Chinese Medicine, 2022. DOI:10. 27253/d. cnki. gnjzu. 2022. 000296. 
[38] Zhang Xin. the effect of Wuhu Decoction through PI3K/Akt/mTOR signaling pathway to regulate DCs autophagy on the proliferation and activation of T cells and the secretion of inflammatory factors in RSV-induced asthmatic mice[D]. Hunan University of Chinese Medicine, 2021. DOI:10. 27138/d. cnki. ghuzc. 2021. 000015. 
[39] Wang Xianzheng. Professor Wang Shouchuan's experience andMechanism of deficiency-excess differentiation in thetreatment of infantile viral pneumonia [D]. Nanjing University of Traditional Chinese Medicine, 2021. DOI: 10. 27253/d. cnki. gnjzu. 2021. 000885. 
[40] Ding Yuewen, Zeng Lijuan, Li Runfeng, etal. Pharmacological Action of Lianhua Qingwen Granules on BALB/c MiceInfected with Respiratory Syncytial Virus [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2016, 33(04):540-544. DOI:10. 13359/j. cnki. gzxbtcm. 2016. 04. 023. 
[41] He Yumin, Wang Jinyan, He Bingjie, etal. Effects of Shaoyao Gancao Decoction on Expression of Inflammatory Factors, Bcl-2 and Bax and Immune Function in RSV-induced Asthma Mice [J]. Journal of Emergency in Traditional Chinese Medicine, 2020, 29(06):1031-1034+1054. 
[42] Li Junying, Li Jiqiang. Effects of Suhuang -zhike capsule on respiratory syncytial virus in vitro experimental study [J]. Hebei Journal of Traditional Chinese Medicine, 2017, 39(04):575-578. 
[43] Wang Jia. Anti-inflammatory effects of BuShen YiQi Formula in RSV-inducedasthma exacerbation mice [D]. Fudan University, 2014. 
[44] Bian Wenqing, Fu Yingxue, Xu Huiqin, etal. Study on the Mechanism of JZKFY Treatment of Cough Induced by Respiratory Syncytial Virus Infection [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2018, 34(03): 277-281. DOI:10. 14148/j. issn. 1672-0482. 2018. 0277. 
[45] Wang Min, Bai Xiaohong, Liu Fang, etal. Effect of Sangpi Zhike Recipe on RSV-induced post-infection coughing miceEffect of c-fos and related inflammatory factors expression [J]. China Journal of Traditional Chinese Medicine and Pharmacy, 2020, 35(12):6038-6042. 

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