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  4. Vol 4, Issue 6, 2023

Differential genes and pathogenesis of sepsis-induced lung injury data analysis

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DOI: 10.23977/medsc.2023.040618 | Downloads: 12 | Views: 293

Author(s)

Jiao Long 1, Lei Zheng 1

Affiliation(s)

1 Surgical Anesthesia Center, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, 518107, China

Corresponding Author

Jiao Long

ABSTRACT

To explore the related differentially expressed genes (differentially expressed gene, DEG) and signal transduction pathways of sepsis-associated lung injury, based on the genomic data of the blood tissue of patients with sepsis-induced lung injury from the Gene Expression Omnibus (GEO) database, gene ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, as well as protein-protein interaction network (PPI) analysis were used to determine the DEG of sepsis-induced lung injury.DEG was significantly enriched in Ribosome, Leishmaniasis, Natural killer cell mediated cytotoxicity and so on. Ten hub genes were screened by PPI analysis, including RPL21, RPL23A, RPL6, RPS18, RPL5, RPL14, RPL23, RPS15A, RPL26, RPL7.Through bioinformatics methods, 10 hub genes related to sepsis-induced lung injury were excavated, which were related to the RPL family and the RPs family.

KEYWORDS

Sepsis; AIDS; Genes; Computational biology

CITE THIS PAPER

Jiao Long, Lei Zheng, Differential genes and pathogenesis of sepsis-induced lung injury data analysis. MEDS Clinical Medicine (2023) Vol. 4: 128-131. DOI: http://dx.doi.org/10.23977/medsc.2023.040618.

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