Author(s)

Dezhan Li, Shuang Han, Tao Xie, Man Li

Corresponding Author

Shuang Han

ABSTRACT

Objective: to observe the influence of Danhong injection on cerebral infarction area and neuron apoptosis rate of rats undergoing cardiopulmonary bypass (CPB) and then discuss cerebral protection effect of Danhong injection. Method: 24 healthy and adult SD rats were divided into sham operation group, CPB group and medicine intervention group at random. Each group includes 8 rats. Cerebral infarction area and neuron apoptosis rate of 3 groups were compared. Results: compared with CPB group, cerebral infarction area of medicine intervention group decreased (P＜0.05). Compared with sham operation group, OD value of apoptotic cells in CPB group rose significantly (P＜0.01). Compared with CPB group, OD value of apoptotic cells in medicine intervention group reduced obviously (P＜0.01). Bax level and Caspase-3 level of CPB group were obviously higher than that of sham operation group, while Bcl-2 was significantly lower than that of sham operation group (P＜0.01). Bax level and Caspase-3 level of medicine intervention group was significantly lower than that of CPB group, while Bcl-2 was significantly higher than that of CPB group (P＜0.01). Conclusion: Danhong injection can play a good cerebral protection role through lowering cerebral infarction area and neuron apoptosis rate.

KEYWORDS

Danhong injection, CPB, rat, cerebral protection