Author(s)

Kun Zhang, Lishen Wang, Shuwei Shen, Aiping Dong, Rong Wang

Corresponding Author

Lishen Wang

ABSTRACT

Objective: to observe the influence of Danhong injection on cerebral s100 (acid calcium coupling protein) protein and NSE (neuron specificenolase) of rats undergoing cardiopulmonary bypass (CPB) and then discuss cerebral protection mechanism of the medicine. Method: 24 SD rats were divided into sham operation group, CPB group and medicine intervention group at random. Each group includes 8 rats. s100 level and NSE level of the 3 groups were compared. Results: NSE level and s100 level in the cerebral tissue homogenate of CPB group rose significantly, compared with sham operation group, P<0.01. The difference was significant. NSE (P<0.01) and S100 (P<0.05) of medicine intervention group declined significantly, compared with CPB group. Conclusion: Danhong injection has certain CPB cerebral protection effect.

KEYWORDS

Danhong injection, CPB, rat, cerebrum, protection effect