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Discussion on Curative Effect and Safety of Small-dosage Alteplase Combined with Urokinase in Treatment of Acute Pulmonary Embolism

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DOI: 10.23977/medeb.2018.07048


Gongchun Fan, Xingguo Peng, Kun Zhang

Corresponding Author

Xingguo Peng


Objective: to discuss curative effect and safety of small-dosage alteplase combined with urokinase in treatment of acute pulmonary embolism. Method: the inclusion time bucket of the objects of this study was from January 2017 to March 2018. Random number table was used to choose 64 patients with acute pulmonary embolism received in our hospital. Then, single blind method was used to classify them into control group and observation group. Each group included 32 cases. The control group received pure urokinase treatment, while the observation group received the treatment by small-dosage alteplase combined with urokinase. The clinical data of both groups were sorted, compared and analyzed in detail. Results: the improvement degree of pulmonary artery systolic pressure and arterial partial pressure of oxygen in the observation group was better than that in the control group. Total effective rate of clinical treatment was 93.75%, higher than that of control group (75.00%), P<0.05. Bleeding rate of observation group was 6.25%, while the bleeding rate of control group was 3.13%, without comparison difference, P>0.05. Conclusion: small-dosage alteplase combined with urokinase has the better clinical effect and higher safety for the patients with acute pulmonary embolism.


Acute pulmonary embolism, alteplase, urokinase, curative effect, safety

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