Author(s)

Zhang Dandan

Corresponding Author

Zhang Dandan

ABSTRACT

Purpose: The purpose of this subject is to explore the expression and significance of clock gene Per2 in non-small-cell lung cancer patient. Method: taking the normal lung tissues of 40 cases of patients received pulmonary cyst and pulmonary bulla surgery of one domestic hospital during April 2015 to August 2017 as control group, perform immunohistochemical staining with the lesion tissue of 40 cases of non-small-cell lung cancer patients of the same period so as to determine the expression of clock gene Per2. Result: the negative expression of clock gene Per2 in non-small-cell lung cancer patients are mainly related to the factors such as differentiation grade, TNM staging, etc(P<0.05), while the Per2 positive expression rate 72.5% is lower than that of normal lung tissue, which is 95%(P<0.05). And the 1 year survival rate, 2 year survival rate and 3 year survival rate are 85%, 62.5%, and 52.5% respectively. Meanwhile, the 3 year survival rate shows correlation (P<0.05)mainly with factors including differentiation grade, TNM staging, lymphatic metastasis, and Per2 positive expression and so on. These 4 pathological indexes, namely differentiation grade, TNM staging, lymphatic metastasis, and Per2 positive expression, are not independent risk factors(P>0.05), but they are influence factors (P<0.05)for the increase of lung cancer death. Conclusion: the expression of clock gene Per2 in non-small-cell lung cancer patient lowers appreciably, and the negative expression plays an important role in the occurrence and development of non-small-cell lung cancer, which has a great influence on prognosis.

KEYWORDS

Circadian clock gene Per2, Non-small-cell lung cancer, Significance of expression, Clinical analysis