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Study on Combined Determination of Serum NT-proBNP and H-FABP Levels for Diagnosis of Acute Heart Failure

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DOI: 10.23977/medeb.2018.07025


Yanmei Guo, Yongwei Li, Yulin Yang, Yanqing Ma

Corresponding Author

Yanmei Guo


To investigate the diagnostic value of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and heart-type fatty acid-binding protein (H-FABP) levels in patients with acute heart failure (AHF), a total of 96 patients with suspected AHF in our hospital from March 2016 to February 2018 were selected as subjects. Electrocardiogram, echocardiography and other imaging examinations and clinical features were used as "gold standard". Serum NT-proBNP and H were detected. -FABP levels were analyzed for their individual detection and combined results, and the value of separate detection and combined detection in the diagnosis of AHF was compared. RESULTS: Of the 96 suspected AHF patients selected in this study, 67 were diagnosed by electrocardiographic and echocardiographic imaging and clinical features. 54 were detected by serum NT-proBNP and 52 were detected by serum H-FABP. 65 cases were detected by combined detection of serum NT-proBNP and H-FABP. The combined detection sensitivity, accuracy, and negative predictive value of serum NT-proBNP and H-FABP were higher than that of serum NT-proBNP and H-FABP alone (P<0.05); the combined detection specificity, positive predictive value, and single detection contrast were not significant. Difference (P>0.05). The combined detection of serum NT-proBNP and H-FABP in early stage of AHF patients has higher sensitivity and accuracy in the diagnosis of diseases, and can provide data support for early clinical prevention and treatment of cardiovascular events, and this method has a high negative predictive value.


NT-proBNP, H-FABP, AHF, diagnostic value

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