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Research on the Changes of Serum Immunoglobulin Levels and Clinical Significance in Patients with Chronic Hepatitis B

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DOI: 10.23977/medeb.2018.07036


Yanmei Guo, Yongwei Li, Yulin Yang, Yanqing Ma

Corresponding Author

Yanmei Guo


Objective: To explore the significance of serum immunoglobulin test in the diagnosis and treatment of hepatitis B patients. Methods: Eighty patients with chronic hepatitis B were selected as study subjects. They were divided into study group A and study group B, with 40 cases in each group. The study group A patients were mild chronic hepatitis B; the study group B patients had severe chronic hepatitis B; 40 healthy people were also selected as the control group. Blood samples were collected from 3 groups of subjects and immunoglobulin (IgA, IgG, IgM) levels, total bilirubin (TBIL) levels, and prothrombin time (PTA) were measured. The test results of the three groups of subjects were compared with the level of immune function after symptomatic treatment. Results: The IgA, IgG, and IgM levels in study group A and study group B were higher than those in the control group, and the indexes in study group B were the highest; after treatment, the effective patients' IgA, IgG, IgM, and TBIL levels were lower than those in the invalid group. Patients, while PTA was higher than that of ineffective patients, the difference was statistically significant (P<0.05). Conclusion: To test the level of serum immunoprotein in patients with hepatitis B can provide scientific basis for the diagnosis of the disease and evaluation of the therapeutic effect, and has high clinical application value.


Serum immunoglobulin level, clinical significance, chronic hepatitis B

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