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Screening and characterization of four β-lactam antibiotic degradation strains PG102

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DOI: 10.23977/fbb2020.023


Zinuo Wang, Yanju Li

Corresponding Author

Yanju Li


In this study, a strain PG102 capable of growing with β-lactam antibiotics as the sole carbon and nitrogen source was isolated from fresh pig manure. Amoxicillin, cefuroxime sodium, and penicillin potassium 3 were cultured within 3 days. Several β-lactam antibiotics were completely degraded and identified as Achromobacter anxifer. Addition of glucose carbon source and NH4Cl nitrogen source can accelerate its degradation. Within 12 hours, amoxicillin, cefuroxime sodium, and penicillin potassium three kinds of mixed antibiotics with a concentration of 100mg / L can be completely degraded. The bacteria can grow at 55℃, have good heat resistance, can be completely degraded at pH 5-9,and the minimum degradation time is 12h at pH 8-9. This provides a reference for the antibiotic environmental pollution treatment of livestock and poultry waste.


PG102, β-lactam, antibiotic

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