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Research Progress in Skin Barrier Function

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DOI: 10.23977/fbb2020.029


Zinan An

Corresponding Author

Zinan An


The skin barrier is mainly composed of keratinized envelope and lipid membrane, intermediate filament polymerized protein, keratin, keratin desmosome, lamellar bodies, and stratum corneum keratinocyte. Its function is to prevent the loss of water and prevent external aggression and maintain a steady state in the body. The combination of genetic mutations, allergens, microorganisms, and ultraviolet rays can cause abnormal skin barrier structure, metabolism, and function, causing skin diseases such as ichthyosis and atopic dermatitis. Clarify the link between skin diseases and barrier structure and functional abnormalities and guide the development of effective diagnostic and preventive measures.


Skin barrier, Barrier structure, Function

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