Author(s)

Juan Yang

Corresponding Author

Juan Yang

ABSTRACT

Atherosclerosis (AS) is the most common and important disease in arteriosclerotic vascular disease, and it is the main pathological basis of ischemic diseases such as coronary heart disease and cerebrovascular disease. Atherosclerosis is an important pathological basis for the occurrence of serious adverse vascular events such as myocardial infarction and stroke, and its essence is a kind of chronic inflammatory disease of blood vessels, which is caused by a variety of stimuli and involved in a variety of factors. The study of pathogenesis and treatment of AS has become a hot topic in medical research, which is an important condition for the study of pathogenesis and treatment of AS to select the right animal model. Considering that rats have strong anti AS characteristics, and their physiological anatomy is similar to that of human beings, so we regard them as experimental animals of AS model. In this paper, we review the development of inflammation mechanism and model replication methods of atherosclerosis..

KEYWORDS

Atherosclerosis, inflammatory mechanism, model replication, pathogenesis