Author(s)

Xuehan Jiang

Corresponding Author

Xuehan Jiang

ABSTRACT

Multiple immunotherapeutic approaches to cancers have recently been developed and got huge success in clinical trials, with the booming of oncolytic virotherapy and immune checkpoint inhibitors. Oncolytic viruses are natural or engineered viruses with the capacity to infect or kill malignant cells without causing damage to normal cells, which could act as a stimulator to anti-tumor immune response and a better tumor microenvironment with immune checkpoint inhibitors treatment. Increasing studies have been reported success with the checkpoint inhibitor treatment with oncolytic viruses, which could significantly enhance the anti-tumor therapeutic efficacy. The strategy is deserved an in-depth study to further improvethe comprehensive and effective treatment of tumors. In this paper, the synergistic effects of oncolytic virus with immune checkpoint inhibitors and its combination therapy are reviewed.

KEYWORDS

Oncolytic viruses, immune checkpoint inhibitors, cancer