Author(s)

Yujie Fu, Yuying Chen, Xiaoliang Chen, Qi Shi, Tian Liu, Yue Liu, Xiang Li, Baoli Duan, Yan Zhang

Corresponding Author

Yan Zhang

ABSTRACT

To study the effects of three kinds of complex probiotics (No.1, No.2 and No.3) on the body weight, intestinal flora and intestinal mucosal function of dysbacteriosis model mice. In this experiment, the model mice with dysbacteriosis caused by antibiotics were taken as the research object. After successful modeling, they were randomly divided into three groups: test group I (gavage of No.1 bacteria), test group II (gavage of No.3 bacteria), test group III (gavage of No.3 bacteria), and normal group and model group without any probiotics. After the middle period of the experiment, the body weight and daily gain of mice during the experimental period were measured Three mice in each group were treated to make tissue sections for morphological observation. The intestinal flora was cultured and counted. The results showed that compared with the model group, continuous supplementation of No. 1 and No. 2 compound probiotics could effectively promote the growth of mice in the state of flora imbalance; Promote the colonization and growth of beneficial bacteria in each intestinal segment, promote the growth of intestinal villi in mice, enhance the absorption of nutrients in the intestine, and increase the ratio of the length of intestinal villi to the depth of glandular fossa. The above results indicated that supplementation of probiotics I and II could obviously relieve stress, promote growth, increase the number of beneficial bacteria in intestinal tract and repair mucosal barrier in mice with dysbacteriosis, which provided theoretical basis for its application in promoting growth and improving intestinal microecosystem of livestock and poultry.

KEYWORDS

Compound probiotics, Dysbacteriosis, Intestinal flora, Mucosal barrier