Author(s)

YaoPeng Ding, William Xie, Jingxuan Liu, Yaxin Zhang

Corresponding Author

YaoPeng Ding

ABSTRACT

Nowadays, Cancer is a focus of concern in immunology research because the effect of existing therapies is very limited. However, monoclonal antibodies have excellent curative effects because of their working mechanism always along with high target-specificity. A clear arrangement is needed on the effective mode of monoclonal antibody drug products in the treatment of different cancers. In this review, we introduced the history of the discovery and developments of mAbs. Besides, the molecular structure, mechanism of action, and classification of mAbs were well illustrated. In addition, we elaborated on the applications of mAbs against lung cancer, breast cancer, leukemia, and lymphatic carcinoma. Overall, mAb is a mighty discovery. In the future, as more reaction mechanisms involved with antigen-antibody binding are studied, the application range of monoclonal antibodies will be more extensive. Therefore, mAb has great potential to solve medical problems.

KEYWORDS

Immunology, monoclonal antibodies (mAbs), lung cancer, breast cancer