Author(s)

Cilong Chu, Zixuan Rao and Shan Xu

Corresponding Author

Shan Xu

ABSTRACT

3-alkyl substituted acrylamidophenol analogues are important intermediates of small molecule antitumor drugs. A rapid and high yield synthetic method for 3-alkyl substituted acrylamidophenol analogues was established in this work. The target compound was synthesized from commercially available 3-nitrophenol through reduction and nucleophilic substitution reactions. The structure of the target product was confirmed by 1HNMR. In addition, the synthesis steps were optimized, and the total yield of the two steps was up to 83%.

KEYWORDS

3-alkyl substituted acrylamidophenol, Synthesis