Author(s)

Feiyi Yang, Xiaohan Hu, Zihan Zhan, Wufu Zhu, Shan Xu

Corresponding Author

Shan Xu

ABSTRACT

Aniline analogs containing different secondary amines are important intermediates of small molecule anticancer drugs. In this work, a rapid synthetic method for target compounds was established. Compounds 2a-c were synthesized from p-nitrochlorobenzene through two steps including reduction reaction and nucleophilic substitution. The structure of the target compounds was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the two steps was up to 56%.

KEYWORDS

Aniline analogs, Secondary amines, Synthesis