Author(s)

Jie He, Zhihui Zhou, Bing Wang, Pengwu Zheng, Shan Xu

Corresponding Author

Shan Xu

ABSTRACT

In recent years, 2, 4-dichloropyrimidine derivatives have found wide application in drug design. In this work, a rapid synthetic method for target compounds was established. Compound (3) was synthesized from 5-amino-1H-pyrazole-4-carboxamide and urea through two steps including cyclization and chlorination. The structure of the target compound was confirmed by 1H NMR and MS spectrum. Furthermore, the synthetic method was optimized. The total yield of the two steps was 49.5%.

KEYWORDS

2, 4-dichloropyrimidine, Synthesis