Author(s)

Xinru Wang

Corresponding Author

Xinru Wang

ABSTRACT

Self-assembly of amphiphilic poly(ethylene glycol)-disulfide-doxorubicin (PEG-SS-DOS) prodrugs yields endosomal redox-responsive micellar nanoparticles. These nanoparticles not only have a simple structure and are simple to prepare, but they also have an excellent storage capacity and stability. The in vitro release of nanoparticles was significantly higher than that of free DOX in the release determination experiment, indicating a high drug loading. The anti-tumor activity of nanoparticles on MCF-7 is superior to that of free DOX, according to CCK-8 results. These benefits hold great promise for the development of prodrug nanomedicine for the treatment of cancer cells.

KEYWORDS

Doxorubicin, Redox-responsive, Prodrug Polymeric nanoparticles