Author(s)

Xingeng Zhao, Zihang Zhuo

Corresponding Author

Xingeng Zhao

ABSTRACT

Long term clinical studies suggest that some lung diseases patients are always experiencing depression after diagnosis. Especially for lung cancer and inflammatory reaction, patients feel depression and even worsen into depressive disorder in a high rate. Recent year, studies about neurotransmitters and hormones are showing that serotonin related pathways could play an important role in triggering depression and finding possible treatments. This review mainly focuses on relative topics and discuss possible direction of future research. Depression disorder is a very common type of mental disorder. Long term clinical studies suggest that patients with some kind of lung diseases sometimes have relative higher risk of experiencing depression after diagnosis. Especially, patients’ feeling of depression might even gradually worsen into depressive disorder. With more and more research and clinical reports about lung disease patients presenting, lung cancer and inflammation on lung are identified as main types of lung diseases that commonly accompany with depression. Recent studies about neurotransmitters and hormones are showing that serotonin related pathways in lung could play an important role in triggering depression and finding possible treatments. Genetic study about mutation in patients’ lung indicate the concentration of serotonin is affected by several different pathways including serotonin re-uptaking and transportation. This review mainly focuses on topics related to serotonin and lung, discussing possible direction of future research.

KEYWORDS

Depressive disorder, lung, serotonin, inflammation, amygdala