Author(s)

Yuheng Geng, Chenxi Li, Haiyang Lin, Yuexuan Liu

Corresponding Author

Yuheng Geng

ABSTRACT

Borderline personality disorder (BPD) is a mental disorder with complex causes. The influencing factors include genetic and environmental factors. This paper mainly concluded twin studies on BPD in recent years. Studies have found that the genetic influence of BPD included methylation caused by childhood maltreat, and some CpG sites on X chromosome that were associated with abnormal methylation levels in BPD patients had been identified. Genetic influence increased with age and tended to stabilize in adulthood. The influence of environmental risk factors on children was greater than on an adult. Maternal BPD trait, improper parenting behavior and discordant marriage of parents showed environmental influence, while the paternal BPD trait and inappropriate behavior (alcoholism, drug addiction, and antisocial behavior) showed genetic influence. In addition, antisocial personality disorder, substance use, loneliness, anxiety disorder, depressive, trait anger and adult attention-deficit hyperactivity disorder may have associations with BPD and most of them showed strong genetic correlations, indicating shared genetic etiological factors.

KEYWORDS

Borderline personality disorder, twin study, genetic factor, environmental factor, comorbidity