Author(s)

Boxiu Deng, Yige Yan

Corresponding Author

Boxiu Deng

ABSTRACT

Sodium channel receptor poisons are a type of neurotoxin that acts on different locations of sodium channels and thus have distinct toxicological effects. Ingestion of these poisons, such as STX, NSTX, TTX, etc., can cause a strong poisoning reaction in the body, and even death. However, recent studies have shown that these neurotoxins can be used to treat pain, such as neuralgia, headaches, based on the characteristics of sodium channels being inhibited by sodium channel blockers. Moreover, a large number of studies have shown that these neurotoxins also have a certain effect on the treatment of cancer. This study investigated the relationship between different sodium channel blockers, including the differences and applications of different sodium channel blockers. This article will focus on the analysis of the three main toxins, The clinical and industrial use of saxitoxin (STX), neurotoxin (NSTX), and tetrodotoxin (TTX) and Introduction to clinical and biological trials of TTX (Tetrodotoxin), and the application of these three toxins in clinical, industrial, and pharmaceutical aspects.

KEYWORDS

Sodium channel blockers, saxitoxin (STX), neurotoxin (NSTX), tetrodotoxin (TTX)