Author(s)

Qihang Yang

Corresponding Author

Qihang Yang

ABSTRACT

Epigenetic regulation of gene function is closely related to the development of cancer. The ability to reprogram the epigenetic landscape in the cancer epigenome is one of the most promising targeted therapies for treatment and reversibility of drug resistance. Epigenetic changes in cancer development and progression may underlie individual differences in drug responses. Over the past decade, our understanding of cancer epigenetics has made significant advances, particularly in abnormal DNA methylation, microRNA (miRNA) and non-coding RNA abnormalities, and altered histone modification states. Evaluation of the main cancer epigenome revealed that almost all cancer had abnormal methylated genes and altered miRNA expression. This review focused on the epigenetic control of cancer therapy and summarized the main regulation way of CAR-T therapy development.

KEYWORDS

DNA Methylation, Histone Modification, Long Noncoding RNA