Author(s)

Weijie He, Chong Xu

Corresponding Author

Weijie He

ABSTRACT

Personality disorders are some of the most common disorders that affect the social life of the patients seriously. For a decade, psychologists studied each of them. The correlation between each disorder and gene has already been studied and analyzed by many researchers as the heritability and environment are calculated. This research provides us with a basic view of the possible cause of these disorders. However, in real life, many patients having one personality disorder is also likely to have another one at the same time, which is also known as the comorbidity of disorder. However, unlike the study of a single disorder, only a few research discussed the comorbidity. In this research, the comorbidity of borderline personality disorder, bipolar disorder, major depression disorder and schizophrenia are studied by several gene and gene set analyses, a genome wide study and LD-score regression and polygenic risk scores. The assessment shows that there is a significant correlation between these four disorders. This study might provide us with a better understanding of personality disorders and give more clues about curing these disorders.

KEYWORDS

Twin study, family study, personality disorder, comorbidity, genome wide study