Author(s)

Xinran Huan, Yixuan Xu

Corresponding Author

Xinran Huan

ABSTRACT

Tau is a microtubule-associated protein (MAPT) that is highly expressed in neurons and participates in multiple cellular processes. Tau misfolding and self-aggregation produce protein deposits called neurofibrillary tangles. The pathological pathway from soluble monomer to insoluble filamentous Tau is considered to be the basis of human Tauopathies. Cases of frontotemporal dementia are caused by a dominant genetic mutation of the Tau gene MAPT. Advanced imaging methods have elucidated important structural and functional aspects of tau, and can be used as a diagnostic tool in clinical research. This review will focus on the latest developments in super-resolution imaging methods, near-infrared fluorescent probes, and positron emission tomography.

KEYWORDS

Tau protein, Super-Resolution Imaging, PET, Near-Infrared Probes