Author(s)

Lu Han

Corresponding Author

Lu Han

ABSTRACT

Diabetes has become one of the serious threats to human health. At present, Clinical drugs for diabetes treatment mainly include insulin, metformin, sulfonylurea and α-glucosidase inhibitor.Theα-glucosidase inhibitor have attracted much attention for their unique advantages in the treatment of typeⅡdiabetes.Natural Chinese herbal medicine has a history of more than 2000 years in the treatment of diabetes, and has rich clinical experience, so it is developed from natural plant materials α- Glucosidase inhibitors are of great significance.Mulberry leaves contain a variety of active substances such as flavonoids, polysaccharides, alkaloids and so on, which have inhibitory effect α - the activity of glucosidase can slow down the rise of blood sugar.Therefore, the treatment of diabetes has been recorded since ancient times.The paper reviewed the main active components of mulberry leaves and its research progress as an inhibitor of α﹣ glucosidase and the mechanism of hypoglycemic action.

KEYWORDS

α-glucosidase inhibitor, mulberry leavesand, hypoglycemic effect