Author(s)

Zhen Liu, Jiangnan Xiao, Haoning Xue

Corresponding Author

Jiangnan Xiao

ABSTRACT

Autism spectrum disorder, is a generalized developmental disorder, whose symptoms include abnormal language skills, abnormal communication skills, narrow interests, and stubborn behavior patterns. Even though the causes of ASD remain uncertain, genetic and neuroscientific studies have identified exciting evidences for people’s understanding. SHANK3 – an actin polymerization modulating gene, and neuroligin, which plays key role in the stability of synapse structure attract increasing attention as research focus and clinical treatment target. With the development of gene therapy technologies, CRIPSPER showed excellent advantages over traditional treatment measures. Accordingly, with going deep into the mechanism of ASD, CRISPER might be a most effective tool for it.

KEYWORDS

Autism spectrum disorder, SHANK3, Neuroligins, CRISPER