Author(s)

Junting Lin

Corresponding Author

Junting Lin

ABSTRACT

Bupleurum is one of the oldest and most used Chinese herbal medicines with a long medicinal history and high medicinal value. Modern pharmacological research shows that the radix Bupleurum has some pharmaceutical effects like antipyretic, analgesic, fall hematic fat, anti-cancer, antidepressant, anti-inflammatory, and protection of the heart, liver, and kidney. They play key roles mainly by regulating apoptosis signaling pathways, inflammation, signaling pathways, neuroendocrine system, oxidative stress signaling pathways, fibrosis, signaling pathways. This paper mainly discusses the main medical effects of Bupleurum, including its effects on healing fever, strengthening the immune system, inhibits tumor cell proliferation, inducing tumor cell apoptosis, Saikosaponin D inhibiting tumor cell invasion and metastasis and regulating tumor cells’ autophagy.

KEYWORDS

Component, Bupleurum, antitumor effect, Saikosaponin D, fever, immunomodulatory effect