Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. Transactions on Cancer
  4. Vol 4, Issue 1, 2023

Regulation of Macrophage Polarization and Tumor Immunosuppression in Glioblastoma

Download as PDF

DOI: 10.23977/tranc.2023.040118 | Downloads: 4 | Views: 223

Author(s)

Yixuan Li 1

Affiliation(s)

1 Beijing 101 Middle School, Beijing, 100000, China

Corresponding Author

Yixuan Li

ABSTRACT

Macrophage polarization is the polarization of a series of functional states after activation of monocytes, and different microenvironmental stimuli can regulate their differentiation. Macrophage is not only an important component of the tumor microenvironment, but also an essential part of it. By interacting with various factors, it regulates the growth, invasion, metastasis, and lymphangiogenesis of the tumor. The increase in the number and density of macrophages such as glioblastoma is closely related to the malignancy of the tumor. Nearly 80% of studies have shown that the number of macrophages in tumor tissues is associated with poor prognosis. Exploring the molecular mechanism of macrophage polarization regulation can contribute to a deeper understanding of the pathogenesis of related diseases and provide new ideas for the development of novel anti-tumor drugs.

KEYWORDS

Glioblastoma, Macrophage, Polarization regulation, Tumor Immunosuppression

CITE THIS PAPER

Yixuan Li, Regulation of Macrophage Polarization and Tumor Immunosuppression in Glioblastoma. Transactions on Cancer (2023) Vol. 4: 126-131. DOI: http://dx.doi.org/10.23977/tranc.2023.040118.

REFERENCES

[1] Fang Xiang, Tian Guopeng, Bai Shengwei, Luo Yusong, Pan Yawen. The role and prospects of DNA-PKcs inhibitors in the treatment of glioblastoma. Journal of International Neurology and Neurosurgery, 2023, 50(1):64-68.
[2] Zhang Jinhao, Liu Peidong, Zhang Chen, Li Jiabo, Ren Xiao, Chen Lulu, et al.ACT001 reduces the expression of programmed cell death protein ligand 1 in glioblastoma cells by inhibiting P65 phosphorylation. Chinese Journal of Contemporary Neurology and Neurosurgery, 2021, 21(6):9-9
[3] Yang Pei, Liu Qi, Tao Rui, Wang Jiangfei. The correlation between the expression of vesicular amine transporter 1 and the immune microenvironment of glioblastoma. Chinese Journal of Neurosurgery, 2022, 38(3):6-6.
[4] Li S, Li L, Chen J, Fan Y, Wang C, Du Y, et al. Liposomal honokiol inhibits glioblastoma growth through regulating macrophage polarization. Annals of Translational Medicine, 2021, 9(22).1644-1644.
[5] Ma J, Chen C C, Li M. Macrophages/microglia in the glioblastoma tumor microenvironment. International journal of molecular sciences, 2021, 22(11): 5775-5775.
[6] Kuntzel T, Bagnard D. Manipulating macrophage/microglia polarization to treat glioblastoma or multiple sclerosis. Pharmaceutics, 2022, 14(2): 344-344.
[7] Yan T, Wang K, Li J, Hu H, Yang H, Cai M, et al. Suppression of the hyaluronic acid pathway induces M1 macrophages polarization via STAT1 in glioblastoma. Cell Death Discovery, 2022, 8(1): 193-193.
[8] Li J, Stanger B Z. Cell cycle regulation meets tumor immunosuppression. Trends in Immunology, 2020, 41(10): 859-863.
[9] Ma H, Kang Z, Foo T K, et al. Disrupted BRCA1‐PALB2 interaction induces tumor immunosuppression and T‐lymphocyte infiltration in HCC through cGAS‐STING pathway. Hepatology, 2023, 77(1): 33-47.
[10] Gao J, Wu Z, Zhao M, et al. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics. Acta Pharmaceutica Sinica B, 2022, 12(1): 149-166.
[11] McKay Z P, Brown M C, Gromeier M. Aryl hydrocarbon receptor signaling controls CD155 expression on macrophages and mediates tumor immunosuppression. The Journal of Immunology, 2021, 206(6): 1385-1394.
[12] Luo Y, Li L, Chen X, et al. Effects of lactate in immunosuppression and inflammation: Progress and prospects. International Reviews of Immunology, 2022, 41(1): 19-29.
[13] Xu Y, Yan J, Tao Y, et al. Pituitary hormone α-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science, 2022, 377(6610): 1085-1091.
[14] Cao X, Wang Y, Zhang W, et al. Targeting macrophages for enhancing CD47 blockade–elicited lymphoma clearance and overcoming tumor-induced immunosuppression. The Journal of the American Society of Hematology, 2022, 139(22): 3290-3302.
[15] Bae J, Accardi F, Hideshima T, et al. Targeting LAG3/GAL-3 to overcome immunosuppression and enhance anti-tumor immune responses in multiple myeloma. Leukemia, 2022, 36(1): 138-154.
[16] Tao N, Li H, Deng L, et al. A cascade nanozyme with amplified sonodynamic therapeutic effects through comodulation of hypoxia and immunosuppression against cancer. ACS nano, 2021, 16(1): 485-501.
[17] Zhang H, Yu P, Tomar V S, et al. Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors. Nature cancer, 2022, 3(7): 808-820.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 427
Visits: 28361

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.