Author(s)

Yan Li ¹, Huang Xiaojia ¹, Liang Junqing ², Qian Weidong ³

Affiliation(s)

¹ Changzhou University, Changzhou, Jiangsu, China
² Hebei Yiling Medicine Institute, Shijiazhuang, Hebei, China
³ Changzhou Wujin Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China

Corresponding Author

Yan Li

ABSTRACT

Endotoxin-induced acute lung injury (ALI) poses a severe challenge to critical care medicine, necessitating a profound understanding of its underlying molecular mechanisms for targeted therapeutic interventions. This comprehensive review explores the hypothetical role of microRNA (miRNA) in modulating the Sun-Luo microvascular system's stability, unraveling potential molecular intricacies contributing to ALI pathogenesis. Moreover, it delves into the therapeutic potential of Ligustrazine (Chuanxiongqin), aiming to decipher its impact on the intricate network of miRNA-mediated signaling pathways in mitigating ALI.

KEYWORDS

Acute Lung Injury (ALI); microRNA (miRNA); "Sun-Luo Microvessels" homeostasis; Rho/ROCK pathway; vascular remodeling

CITE THIS PAPER

Yan Li, Huang Xiaojia, Liang Junqing, Qian Weidong, Precision Medicine Unveiled: Deciphering the Molecular Tapestry of Endotoxin-Induced Acute Lung Injury through microRNA Modulation and Exploring the Therapeutic Nexus with Ligustrazine in the Sun-Luo Microvascular System. MEDS Chinese Medicine (2024) Vol. 6: 9-16. DOI: http://dx.doi.org/10.23977/medcm.2024.060102.

REFERENCES

[1] Huang M, Cai SL, Su JQ. (2019). The Pathogenesis of Sepsis and Potential Therapeutic Targets. International Journal of Molecular Sciences, 20(21), 5376.
[2] Zhang JH, Tian WY, Wang F, et al. (2023). Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury. Cell Cycle, 22(14-16): 1694-1712.
[3] Chang CC, Wei C, Wu YL. (2016). "Minute Collaterals and Microvessels" Concept and Its Clinical Guiding Significance in Meridian and Collateral Theory. Jounal of Traditional Chinese Medicine, 57(01), 7-11. 
[4] Kimura M, Kothari S, Gohir W, et al. (2016). MicroRNAs in infectious diseases: potential diagnostic biomarkers and therapeutic targets. Clinical Microbiology Reviews, 36(4), e00015-23. 
[5] Yuan YH, Yuan R, Xin QQ, et al. (2024). Tetramethylpyrazine and paeoniflorin combination (TMP-PF) inhibits angiogenesis in atherosclerosis via miR-126/VEGF/VEGFR2 signaling pathway. Journal of Future Foods, 4(3), 280-287.

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