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Research Progress of the Effect and Mechanism of Active Ingredients of Astragalus Membranaceus on Tumor

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DOI: 10.23977/medcm.2024.060115 | Downloads: 7 | Views: 158

Author(s)

Meihuan Fu 1, Xiaofeng Zhai 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Oncology Department of Traditional Chinese Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China

Corresponding Author

Xiaofeng Zhai

ABSTRACT

Chinese herbal medicine has a long history of treating malignant tumors in China and is considered to be effective in improving the survival. As a traditional Chinese medicine, the immunomodulatory, anti-tumor, anti-inflammatory, anti-aging and anti-hypertensive effects of Astragalus membranaceus have been confirmed by modern pharmacological studies. The main active components of Astragalus membranaceus are astragaloside, astragalus polysaccharide and flavonoids, and all have antitumor effects. The effects of Astragalus membranaceus active substances on tumors by inhibiting tumor proliferation, invasion and metastasis and regulating the immune function of the body are briefly discussed to increase the theoretical understanding of the antitumor effects of Astragalus membranaceus in order to provide reference and help for theoretical ideas in the clinical treatment of its antitumor effects.

KEYWORDS

Astragalus membranaceus, astragalus polysaccharide, astragaloside, flavonoid, antitumor, mechanism of action

CITE THIS PAPER

Meihuan Fu, Xiaofeng Zhai, Research Progress of the Effect and Mechanism of Active Ingredients of Astragalus Membranaceus on Tumor. MEDS Chinese Medicine (2024) Vol. 6: 106-112. DOI: http://dx.doi.org/10.23977/medcm.2024.060115.

REFERENCES

[1] SUNG H, FERLAY J, SIEGEL R L, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J]. CA Cancer J Clin, 2021, 71(3): 209-249.
[2] LIU J, PANDYA P, AFSHAR S. Therapeutic Advances in Oncology [J]. Int J Mol Sci, 2021, 22(4).
[3] LI S, SUN Y, HUANG J, et al. Anti-tumor effects and mechanisms of Astragalus membranaceus (AM) and its specific immunopotentiation: status and J Ethnopharmacol, J Ethnopharmacol, J Ethnopharmacol. J Ethnopharmacol, 2020, 258: 112797.
[4] FU J, WANG Z, HUANG L, et al. Review of the botanical characteristics, phytochemistry, and pharmacology of Astragalus membranaceus (Huangqi) [J]. Phytother Res, 2014, 28(9): 1275-1283.
[5] CHEN G H, HUANG W F. Progress in pharmacological effects of compositions of Astragalus membranaceus [J]. Chinese Journal of New Drugs, 2008, 17(17): 1482-1485.
[6] LI L, CHANG-JIN Y, JING-JIE G, et al. Inhibitory effect of astragalus polysaccharide on the proliferation of HepG2 cells and its potential mechanism [ J]. Practical Preventive Medicine, 2018.
[7] HUIRONG Z, MIN Q, MENG L. Astragalus polysaccharides inhibitith epatocellular carcinoma cells through mitochondrialautophagy [J]. Northwest Pharmaceutical Journa, 2021, 36(03): 426-429.
[8] HOESEL B, SCHMID J A. The complexity of NF-κB signaling in inflammation and cancer [J]. Mol Cancer, 2013, 12: 86.
[9] WU C, ZHANG Y, YE T, et al. Inhibition of nuclear factor-kappa B mediated anti-tumor activity of Astragalus polysaccharide in human lung cancer cells [J]. Medical Journal of Wuhan University, 2013, 34(2): 174-177.
[10] WANG T, XUAN X, LI M, et al. Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells [J]. Diagn Pathol, 2013, 8: 179.
[11] HE Y, ZHANG Q, CHEN H, et al. Astragaloside IV enhanced carboplatin sensitivity in prostate cancer by suppressing AKT/NF-κB signaling pathway [J]. Biochem Cell Biol, 2021, 99(2): 214-222.
[12] LAI S T, WANG Y, PENG F. Astragaloside IV sensitizes non-small cell lung cancer cells to cisplatin by suppressing endoplasmic reticulum stress and autophagy [J]. J Thorac Dis, 2020, 12(7): 3715-3724.
[13] YAN-QING C, PHARMACY D O. Mechanism of Astragaloside Ⅱ combined with 5-fluorouracil in inhibiting liver cell proliferation [J]. Journal of Hainan Medical University, 2016.
[14] PARK S, BAZER F W, LIM W, et al. The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation [J]. J Cell Biochem, 2018, 119(9): 7377-7387.
[15] ZHANG Y, CHEN C, ZHANG J. Effects and significance of formononetin on expression levels of HIF-1α and VEGF in mouse cervical cancer tissue [J]. Oncol Lett, 2019, 18(3): 2248-2253.
[16] TIAN J, WANG Y, ZHANG X, et al. Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling [J]. J Exp Clin Cancer Res, 2017, 36(1): 153.
[17] ZHANG D, SUN G, PENG L, et al. Calycosin inhibits viability, induces apoptosis, and suppresses invasion of cervical cancer cells by upregulating tumor suppressor miR-375 [J]. Arch Biochem Biophys, 2020, 691: 108478.
[18] BING Y, GUI-HONG Y U, MING-YU L I, et al. Mechanism of flavonoid components in Astragali Radix in inhibiting tumor growth and immunoregulation in C57BL/6 tumor bearing mice based on "invigorating Qi for consolidation of exterior" [J]. China Journal of Chinese Materia Medica, 2019.
[19] CAMUZARD O, SANTUCCI-DARMANIN S, CARLE G F, et al. Autophagy in the crosstalk between tumor and microenvironment [J]. Cancer Lett, 2020, 490: 143-153.
[20] QI Y, YING D J, LIN W X, et al. Effect and mechanism of Astragalus polysaccharides on autophagy in lung cancer A549 cells [J]. Chin J Clin Pharmacol, 2022, 38(12): 1329-1333.
[21] FANG D, LIJIANG D. Mechanism of Astragalus polysaccharide in inhibiting proliferation of human hepatocellular carcinoma cells [J]. West China Journal of Pharmaceutical Sciences, 2020, 35(04): 402-406.
[22] ZHANG ZHIHONG, WANG CHUNMEI, LI HE, et al. Astragaloside IV Inhibits Proliferation and Migration of Lung Cancer Cells through JAK / STAT3 Signaling Pathway [J]. Journal of Beihua University (Natural Science ), 2022, 23(06): 775-779.
[23] MIN W, XI Z, YAN Q, et al. Effect and Mechanism of Astragaloside II on Pulmonary Metastatic of Hepatoma in Mice [J]. Pharmacology and Clinics of Chinese Materia Medica, 2019, 35(06): 41-45.
[24] YAN C, QIANCHUAN R. Mechanism of astragaloside on proliferation, migration and invasion of ovarian cancer cell SKOV3 [J]. Chinese Journal of Clinical Research 2020, 33(06): 743-748.
[25] TAN J, QIN X, LIU B, et al. Integrative findings indicate anti-tumor biotargets and molecular mechanisms of calycosin against osteosarcoma [J]. Biomed Pharmacother, 2020, 126: 110096.
[26] KISHTON R J, SUKUMAR M, RESTIFO N P. Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy [J]. Cell Metab, 2017, 26(1): 94-109.
[27] BOULCH M, CAZAUX M, CUFFEL A, et al. Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4(+) CAR T-cell antitumor activity [J]. Nat Cancer, 2023, 4(7): 968-983.
[28] MIN W, XI Z, XIAOJIAO P, et al. Anti-tumor Immunological Mechanism of Astragaloside II through Activating CD45 PTPase [J]. Journal of Yunnan University of Traditional Chinese Medicine, 2021, 44(02): 1-6.
[29] HUANG W C, KUO K T, BAMODU O A, et al. Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade [J]. Cancers (Basel), 2019, 11(8).
[30] PAUST S, LU L, MCCARTY N, et al. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease [J]. Proc Natl Acad Sci U S A, 2004, 101(28): 10398-10403.
[31] LI Q, BAO J M, LI X L, et al. Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma [J]. Chin Med J (Engl), 2012, 125(5): 786-793.
[32] CHENG X, GU J, ZHANG M, et al. Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway [J]. Int Immunopharmacol, 2014, 23(1): 304-313.
[33] KLOOSTERMAN D J, AKKARI L. Macrophages at the interface of the co-evolving cancer ecosystem [J]. Cell, 2023, 186(8): 1627-1651.
[34] SICA A, MANTOVANI A. Macrophage plasticity and polarization: in vivo veritas [J]. J Clin Invest, 2012, 122(3): 787-795.
[35] LIU F, RAN F, HE H, et al. Astragaloside IV Exerts Anti-tumor Effect on Murine Colorectal Cancer by Re-educating Tumor-Associated Macrophage [J]. Arch Immunol Ther Exp (Warsz), 2020, 68(6): 33.

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