Author(s)

Yunhao Lei ¹

Affiliation(s)

¹ College of Medical Imaging, Dalian Medical University, Dalian, Liaoning, 116000, China

Corresponding Author

Yunhao Lei

ABSTRACT

Although some progress has been made in cancer treatment, there are still challenges such as tumor cell escape and recurrence after treatment. This article analyzed tumor surface antigens and their specificity, and designed antigen receptors for Chimeric Antigen Receptor T-Cell (CAR-T) targeting tumor cells. This article intended to use gene encoding techniques such as CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-associated protein 9) to precisely regulate CAR-T cells and improve their therapeutic efficacy. On this basis, using in vitro amplification, culture and other methods, the large-scale production of CAR-T cells was achieved to ensure the sustained and stable therapeutic effect. This article tracked the therapeutic effects of mouse models and clinical trials on patients for a long time, and evaluated the persistence and stability of CAR-T combined with immunosuppressive agents. The survival time of CAR-T cells in vivo and their long-term inhibitory effect on tumors were analyzed. After using CAR-T treatment, the survival time of CAR-T cells was 120 days. The recurrence time of the tumor was 180 days, which was significantly longer than the 30 days in the tumor control group, indicating that CAR-T treatment has a certain effect on delaying tumor recurrence. This article comprehensively evaluated the efficacy and mechanism of CAR-T combined with immunosuppressive agents in tumor treatment, providing important scientific basis and experimental support for future clinical applications.

KEYWORDS

Tumor Treatment, CAR-T Method, Immunosuppressive Agents, Recurrence Time

CITE THIS PAPER

Yunhao Lei, Application of CAR-T Combined with Immunoassay Inhibitors in Tumor Treatment. MEDS Clinical Medicine (2024) Vol. 5: 144-151. DOI: http://dx.doi.org/10.23977/medsc.2024.050122.

REFERENCES

[1] Myakoshina E B, Saakyan S V. A rare case of eye complications of gastric stromal tumor treatment using imatinib mesylate. Russian Ophthalmological Journal, 2020, 13(3):88-91.
[2] Huan-Huan Wen, Hui-Yuan Wu, Yan-Fei Yi, Lu Xiao, Zi-Yang Li, Xi-Ya Yuan, Yang Liu, Zi-Yan Huang."Endogenous wind "Theory theory in the prevention and treatment of anti-tumor treatment-related adverse reaction related research progress. TMR tumor progression, 2021, 4(6):14-18.
[3] Peng Z B.Screening of traditional Chinese medicine monomers as ribonucleotide reductase M2 inhibitors for tumor treatment. World Journal of Clinical Cases, 2022, 10(31):11299-11312.
[4] Akakuru O U, Zhang Z, Iqbal M Z, et al. Chemotherapeutic nanomaterials in tumor boundary delineation: Prospects for effective tumor treatment. Journal of Pharmacy: English Edition, 2022, 12(6):2640-2657.
[5] Du Y, Liu D, Sun M, et al. Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment. Nanoresearch: English version, 2022, 15(3):2288-2299.
[6] Cho H R, Kim M, Lee J, et al. Penetrative and Sustained Drug Delivery Using Injectable Hydrogel Nanocomposites for Postsurgical Brain Tumor Treatment. ACS Nano, 2023, 17(6):5435-5447.
[7] Tao Xin, Hou Qian, Li Ping. Exploration of the Application of Rapid Rehabilitation Concept Combined with Traditional Chinese Medicine Nursing Model - Taking Its Application in the Treatment of Gynecological Malignant Tumors as an Example. Clinical Application Research on Nursing and Health Care, 2023, 1 (1): 37-39.
[8] Chen Jiawen, Huang Jiandong, Sun Haitao. The application progress of engineering bacteria in tumor treatment. Synthetic Biology, 2023, 4 (4): 690-702.
[9] Shan Bao'en. Outlook for tumor treatment in the era of post PD-1/PD-L1 inhibitors. Research on Cancer Prevention and Treatment, 2023, 50 (9): 833-841.
[10] He Yiman, Zhang Liang, Wang Dong. Research progress on the combination of 3-bromopyruvate and nanomaterials for tumor treatment. Chongqing Medical Journal, 2022, 51 (2): 331-335.
[11] Chen Y, Wang S, Chen L,et al. Amplification and Bioinformatics Analysis of h-ns Gene of Vibrio alginolyticus. Asian Agricultural Research, 2023, 15(4):29-33.
[12] Shen H, Ren S, Wang W, et al. Profiles of immune status and related pathways in sepsis: evidence based on GEO and bioinformatics. BIOCELL, 2020, 44(4):583-589.

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