Author(s)

Ni Tianyu ¹

Affiliation(s)

¹ Wenzhou Medical University, Wenzhou, 325000, China

Corresponding Author

Ni Tianyu

ABSTRACT

Because the incidence of coronary heart disease is gradually increasing, its harm has been widely paid attention to, coronary heart disease is generally treated by drug therapy, so modern clinical focus on the study of coronary heart disease patients with drug therapy effect. In this study, 80 patients with coronary heart disease admitted to our hospital from November 2022 to November 2023 were selected. After randomization, the control group was given single drug treatment, while the observation group was required to take atorvastatin calcium tablets combined with cardiovascular drugs. Blood lipid indexes [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), albumin] before and after treatment were compared between the two groups. Cardiac function indicators (left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic diameter (LVESV), left ventricular ejection fraction (LVEF)) before and after treatment; Hemorheological parameters (hemoglobin (Hb), hematocrit (HCT), erythrocyte volume (MCV), platelet count (PCT)) before and after treatment; Total effective rate of treatment; The incidence of adverse reactions was analyzed, and then the therapeutic effect of atorvastatin calcium tablets combined with cardiovascular drugs was analyzed. Through analysis, it was found that after treatment, blood lipid indexes, cardiac function indexes and hemorheology indexes of patients in the two groups were significantly improved compared with those before treatment, and the above indexes of patients in the observation group were superior to those in the control group. At the same time, the total effective rate of clinical treatment in the observation group was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group, showing significant differences between the two groups. According to the results of this study, atorvastatin calcium tablets combined with cardiovascular drugs can improve the cardiac function and blood indexes of patients with coronary heart disease, and the clinical effect and safety are relatively high, which is worthy of promotion.

KEYWORDS

Atorvastatin calcium tablets; cardiovascular drugs; coronary heart disease; clinical efficacy; safety

CITE THIS PAPER

Ni Tianyu, Clinical Study on the Treatment of Coronary Heart Disease with Atorvastatin Calcium Tablets in Combination with Cardiovascular Drugs. MEDS Clinical Medicine (2024) Vol. 5: 30-35. DOI: http://dx.doi.org/10.23977/medsc.2024.050204.

REFERENCES

[1] Valadez R M J, Tahsin M, Masharani U, et al.Potential Mediators for Treatment Effects of Novel Diabetes Medications on Cardiovascular and Renal Outcomes: A Meta-Regression Analysis.[J].Journal of the American Heart Association, 2024, 13(4):e032463-e032463.
[2] Jiang L J, Huang J Q, Chen H M .Efficacy and safety of drug-coated balloon for de novo lesions of large coronary arteries: Systematic review and meta-analysis of randomized controlled trials.[J]. Heliyon, 2024, 10(3): e25264-e25264.
[3] Abdul A R, Suveenkrishna P, Adeel S H, et al.Long-Term Efficacy and Safety of Drug-Eluting Stent Versus Drug-Coated Balloon for De Novo Lesions in Small-Vessel Coronary Disease: A Systematic Review and Meta-Analysis[J].Cardiovascular Revascularization Medicine, 2021, 28(S):S22-S25.
[4] Yue D, Ling W, Lingmin F, et al. The efficacy and safety of domestic and imported rapamycin drug-eluting stents and paclitaxel drug-coated balloons in the treatment of coronary bifurcation lesions.[J].American journal of translational research, 2021, 13(8):9421-9428.
[5] Kutikuppala S V L, Sharma S, Chavan M, et al.Bromocriptine: does this drug of Parkinson's disease have a role in managing cardiovascular diseases?[J].Annals of medicine and surgery (2012), 2024, 86(2):926-929.
[6] Cao Z Y, Zheng L G, Zhang Q T, et al.Hepatic arterial infusion chemotherapy with anti-angiogenesis agents and immune checkpoint inhibitors for unresectable hepatocellular carcinoma and meta-analysis.[J].World journal of gastroenterology, 2024, 30(4):318-331.
[7] Mahmoud R, Arbel S, Ianculovici C, et al.Antimicrobial therapy in the management of odontogenic infections: the penicillin-allergic patient.[J].International journal of oral and maxillofacial surgery, 2024, 53(3):251-257.
[8] Lin Y, Jianjun Q, Jian D, et al.Comparison of mid-outcome among bare metal stent, atherectomy with or without drug-coated balloon angioplasty for femoropopliteal arterial occlusion.[J].Scientific reports, 2024, 14(1):63-65.
[9] Suárez G S, Serrano A H, Chocron Z I, et al.Postreperfusion Syndrome in Patients Receiving Vasoactive Drugs During Liver Graft Reperfusion.[J].Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2024, 22(1):43-51.
[10] Kumar A, Kumar J, et al. Comparative Efficacy of Anti-vascular Endothelial Growth Factor (Anti-VEGF) Agents and Corticosteroids in Managing Diabetic Retinopathy-Associated Diabetic Macular Edema: A Meta-Analysis and Comprehensive Systematic Review.[J].Cureus, 2024, 16(1):e51910-e51910.
[11] Bhavarth D, Kaif M, Nisha P, et al. Comprehensive Review on Analytical and Bioanalytical Methods for Quantification of Anti-angiogenic Agents used in Treatment of Cervical Cancer[J].Current Pharmaceutical Analysis, 2024, 19(10):735-744.
[12] Hema M, Mandy M, Christina C, et al. Subthreshold micropulse laser versus standard laser for the treatment of central-involving diabetic macular oedema with central retinal thickness of 400µ: a cost-effectiveness analysis from the DIAMONDS trial.[J]. BMJ open, 2023, 13(10):e067684-e067688.
[13] Steffi H, Maggie B, Elmar S, et al. Applicability of magnetic seeds for target lymph node biopsy after neoadjuvant chemotherapy in initially node-positive breast cancer patients: data from the AXSANA study.[J].Breast cancer research and treatment, 2023, 202(3):497-504.
[14] Wanying B, Zhengyu L .Efficacy and safety of neoadjuvant chemotherapy containing anti-angiogenic drugs, immunotherapy, or PARP inhibitors for ovarian cancer.[J].Critical reviews in oncology/hematology, 2023, 194104238- 104238.
[15] K. L S A. Effect of a Standardized Family Participation Program in the ICU: A Multicenter Stepped-Wedge Cluster Randomized Controlled Trial*[J].Critical Care Medicine, 2024, 52(3):505-506.

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