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  4. Vol 5, Issue 2, 2024

Diagnosis of Antibiotic-Resistant K. Pneumoniae Sepsis by Serum Inflammatory Factors and Microbial Tests

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DOI: 10.23977/medsc.2024.050209 | Downloads: 18 | Views: 179

Author(s)

Jiaran Sun 1, Ruifeng Yang 1

Affiliation(s)

1 Department of Clinical Laboratory, Peking University Shougang Hospital, Beijing, 100144, China

Corresponding Author

Ruifeng Yang

ABSTRACT

This study aimed to investigate multidrug-resistant K. Pneumoniae sepsis through the combination of serum inflammatory factors and microbiological testing. Clinical data from 321 cases were analyzed: 50 patients suffered from sepsis caused by multidrug-resistant K. Pneumoniae (Group A), 221 patients with sepsis caused by other infections (Group B), and 50 healthy individuals undergoing physical examinations during the same period (Group C). Laboratory tests were conducted for all three groups, and the data were comprehensively analyzed. The results showed that the levels of inflammatory factors including procalcitonin (PCT), interleukin-6 (IL-6) and C-reactive protein (CRP) in group A were significantly higher than those in groups B and C (P<0.001). Furthermore, Group B patients had significantly higher inflammatory factor levelsthan Group C patients (P<0.001). Among the 452 strains of pathogens isolated from these sepsis patients, there were 302 strains of gram-negative bacteria, including 50 strains of multidrug-resistant K. Pneumoniae, accounting for 11.06% (50/452). There were 120 strains of gram-positive bacteria and 30 fungal strains. The resistance rate of K. Pneumoniae to cefazolin, cefotaxime, ceftazidime, cefepimea and aztreonam was over 44%. The resistance rate of K. Pneumoniae to imipenem, meropenem was over 40%. In conclusion, more attention should be paid to the clinical treatment of patients with multidrug-resistant K. Pneumoniae sepsis, and laboratory tests reflecting disease progresses such as the levels of serum inflammatory factors should be timely performed.

KEYWORDS

Multidrug-resistant K. Pneumoniae; Sepsis; Serum inflammatory factors; Microbiology

CITE THIS PAPER

Jiaran Sun, Ruifeng Yang, Diagnosis of Antibiotic-Resistant K. Pneumoniae Sepsis by Serum Inflammatory Factors and Microbial Tests. MEDS Clinical Medicine (2024) Vol. 5: 60-64. DOI: http://dx.doi.org/10.23977/medsc.2024.050209.

REFERENCES

[1] Angus D C, Linde-Zwirble W T, Lidicker J, et al. Epidemiology ofsevere sepsis in the United States: analysis of incidence, outcome, and associated costs of care [J]. Critical care medicine, 2001, 29(7): 1303-1310.
[2] Timbrook TT, Morton JB, McConeghy KW, et al. The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis. Clin Infect Dis, 2017, 64:15.
[3] Kang CI, Kim SH, Bang JW, et al. Community-acquired versus nosocomial Klebsiella pneumoniae bacteremia: clinical features, treatment outcomes, and clinical implication of antimicrobial resistance. J Korean Med Sci, 2006, 21:816.
[4] Lupetti A, Barnini S, Dodi C, et al. New rapid methods cannot replace the current method to diagnose bloodstream infections [J]. Journal of Medical Microbiology, 2014, 63(5):767-769.
[5] Clerc O, Prod’hom G, Vogne C, et al. Impact of matrix-assisted laser desorption ionization time-of-flight mass spectrometry on the clinical management of patients with Gram-negative bacteremia: a prospective observational study. Clin Infect Dis. 2013, 56:1101-1107.
[6] Rahimian J, Wilson T, Oram V, et al. Pyogenic Liver Abscess: Recent Trends in Etiology and Mortality [J]. Clinical Infectious Diseases, 2004, 39(11):1654-1659.
[7] Singer M, Deutschman C S, Seymour C W, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) [J]. The Journal of the American Medical Association, 2016, 315(8):775-787.
[8] Hauck C, Cobeｒ E, Ｒichteｒ SS, et al. Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections [J]. Clin Microbi and Infect, 2016, 22(6): 513-519.
[9] Liu Hui, Zhao Peiran, Guan Limei, et al. Correlation analysis of serum Presepsin, inflammatory factors and prognosis in children with sepsis. Chinese Journal of Nosocomial Infectiology, 2020, 30:438-442.
[10] CAI Rong, Chen Xuemei, Qi Huiyan, et al. Correlation analysis of serum H2S, GDF-15, PTX-3 levels with coagulation function, inflammation index and disease score in patients with sepsis. Advances in Modern Biomedicine, 2012, 21:1365-1369.
[11] Lu Ming, Li Jiajun. Effects of ulinastatin combined with thymosin α1 on T lymphocyte subsets and inflammatory factors in peripheral blood of patients with sepsis. Trauma and Critical Care Medicine, 2018, 6: 369-371,374.
[12] Zhang Qian, Fu Jinyue, Li Dandan, et al. Clinical analysis of septic shock in hematological diseases. Journal of Harbin Medical University, 2021, 55:278-281.
[13] Liu Chen. Clinical value of PCT and CRP changes, bacterial culture and drug sensitivity analysis in patients with urinary sepsis. Hebei Medical University, 2017.

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