Author(s)

Yang Shen ¹

Affiliation(s)

¹ Deyang People's Hospital, Deyang, Sichuan, 618000, China

Corresponding Author

Yang Shen

ABSTRACT

This study aims to explore the application value of serum cytokine levels (TNF-α, IL-6, IL-10, IFN-γ) and disease activity scores in assessing the disease activity of inflammatory bowel disease (IBD). This experiment adopts a prospective study design, with a total of 100 subjects, including 50 IBD patients (experimental group) and 50 healthy controls (control group), over a duration of 6 months. The levels of TNF-α, IL-6, IL-10, and IFN-γ in serum were measured using the ELISA method, while the disease activity scores of patients were recorded. Data processing was carried out using SPSS software, and a P value of less than 0.05 was considered statistically significant. The levels of TNF-α, IL-6, IFN-γ, and Mayo scores in the experimental group were significantly higher than those in the control group (P < 0.05), while the level of IL-10 was significantly lower than that in the control group (P < 0.05). These results indicate that IBD patients have significant inflammatory responses and higher disease activity. The elevation of TNF-α, IL-6, and IFN-γ in serum, along with the reduction of IL-10 and the increase in disease activity scores, can serve as effective indicators for assessing the disease activity of IBD. The detection of these biomarkers is of great significance for the diagnosis and treatment monitoring of IBD.

KEYWORDS

Inflammatory bowel disease; TNF-α; IL-6; IL-10; IFN-γ

CITE THIS PAPER

Yang Shen, The Application Value of Serum Cytokine Levels in Assessing the Disease Activity of Inflammatory Bowel Disease . MEDS Clinical Medicine (2024) Vol. 5: 84-88. DOI: http://dx.doi.org/10.23977/medsc.2024.050213.

REFERENCES

[1] Chen Xiaotian, Huo Lijuan. A meta-analysis of the clinical significance of serum total bilirubin levels in inflammatory bowel disease [J]. Clinical Collection, 2023, 38(8): 677-685.
[2] Wei Yarong, Chen Tingting, Yang Wu, et al. Clinical significance of serum anti-CABP levels in patients with inflammatory bowel disease [J]. Chinese Journal of Inflammatory Bowel Disease, 2021, 5(1):7
[3] Dong Rui, Xue Linglong. Relationship between serum miR-21, HMGB1 levels and Th1/Th2 balance in patients with inflammatory bowel disease [J]. Shandong Medicine, 2023, 63(19): 46-49.
[4] Shao Xiaona, Shen Ruiwei, Lu Ting, et al. Exploration of the relationship between serum calcium ion levels and disease activity in inflammatory bowel disease [J]. Zhejiang Medicine, 2021, 43(16): 4.
[5] Yang Hong, Zhang Mingguang, Wang Zhidong, et al. Study on the correlation between serum immune-inflammatory related protein complex, 25-hydroxyvitamin D, adipocytokines and disease activity and intestinal flora in patients with inflammatory bowel disease [J]. Advances in Modern Biomedicine, 2022, 22(14): 5.

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