Education, Science, Technology, Innovation and Life
Open Access
Sign In
  1. Home
  2. Journals
  3. Transactions on Cancer
  4. Vol 5, Issue 1, 2024

Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours

Download as PDF

DOI: 10.23977/tranc.2024.050107 | Downloads: 1 | Views: 55

Author(s)

Shichao Yuan 1

Affiliation(s)

1 School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China

Corresponding Author

Shichao Yuan

ABSTRACT

The objective of the study is to analyse the value of serum-mediated levels of cell adhesion molecule-1 (ICAM-1), matrix metalloproteinase-9 (MMP-9), tumour necrosis factor-alpha (TNF)-alpha) and interleukin-6 (IL-6) in the early diagnosis of brain tumours. Serum samples were collected from 100 brain tumour patients and 100 healthy controls. The serum levels of ICAM-1, MMP-9 and TNF -α compared with IL-6 were detected by enzyme-linked immunosorbent assay (EIA), and the results were statistically analysed. The results show that the levels of ICAM-1, MMP-9 and TNF in serum of brain tumour patients- α IL-6 and IL-6 were significantly higher (P<0.01). The sensitivity and specificity of serum ICAM-1, MMP-9, and TNF- α IL-6 for the diagnostic thresholds determined by receiver operating characteristic curve (ROC) analysis were 85% and 80%, 78% and 84%, 82% and 76%, and 76% and 79%, respectively. CONCLUSION: Serum ICAM-1, MMP-9, TNF- α and IL-6 levels have high diagnostic value for the early diagnosis of brain tumours, and can be used as effective biomarkers for early screening and diagnosis of brain tumours.

KEYWORDS

Brain tumors; ICAM-1; MMP-9; TNF- α; IL-6

CITE THIS PAPER

Shichao Yuan, Clinical diagnostic value of serum ICAM-1, MMP-9, TNF-α and IL-6 in patients with early brain tumours. Transactions on Cancer (2024) Vol. 5: 47-52. DOI: http://dx.doi.org/10.23977/tranc.2024.050107.

REFERENCES

[1] Zhao Xiaofen, Yang Mifeng, Hao Tingting, etc. Cerebrospinal fluid TNF- α And IFN- γ the significance of detection in the diagnosis of neonatal purulent meningitis [J]. Laboratory Medicine and Clinical, 2023, 20 (14): 2045-2047+2052.
[2] Liu Zhisu. Serum BDNF, IGF-1, CRP, TNF in PD patients- α A study on the correlation between level and movement disorders [D]. Guilin Medical College, 2023 DOI: 10.27806/dcnki.gglyx.2023.000178. 
[3] Angelo C, Teresa C, Flavio C, et al. Targeting the Blood – Brain Tumor Barrier with Tumor Necrosis Factor- α [J]. Pharmaceutics, 2022, 14 (7): 1414-1414.
[4] Ai Jie, Liu Hongbo, Chen Huoying. Dexamethasone inhibits TNF- α Induced expression/release of IL-33 and related pathways [C]//Chinese Immunological Society Compilation of abstracts from the 14th National Immunology Academic Conference Guilin Medical College; 2021: 1 DOI: 10.26914/c.cnkihy.2021.071237.
[5] Young J Y, Jessica S, Yoshihiro O, et al. oHSV therapy increases trametinib access to brain tutors and senses them in vivo [J]. Neuro oncology, 2019, 21 (9): 1131-1140.
[6] Yu Haina, Liu Yongdan, Li Yanhua. Serum soluble intercellular adhesion molecule-1, signal transduction and transcriptional activators 4, and tumor necrosis factor in patients with cerebral infarction- α Level and clinical significance [J]. Chinese Journal of Clinical Health, 2019, 22 (02): 196-199.
[7] Hui Zheng, Zhi Pan. Expression of ICAM-1, LFA-1 and VEGFR-3 in human breast cancer tissues in relation to lymphatic metastasis[J]. Journal of Medical Research, 2009, 38(1):5.
[8] Shicai H, Guimei W, Jingjing L, et al. Hyperbaric oxygen on metabolism of brain tumors after surgery and effects on TNF- α And IL-6 levels [J]. Oncology letters, 2019, 17 (3): 3277-3282.
[9] Chang Jiukui, Liu Xiaorong, Zheng Jianhui, etc. The effect of aprotinin on serum inflammatory factor levels in patients undergoing brain tumor surgery [J]. Journal of Practical Cancer, 2016, 31 (09): 1436-1437.
[10] Zhang Junshi, Chang Na, He Weiya. ET-1 and TNF in hypertensive intracerebral hemorrhage patients- α Changes in NO levels and their correlation [J]. Chinese Health Standard Management, 2015, 6 (26): 22-23.
[11] Liang Shaodong, Li Hongzhe, Zhuang Yayan. Exploring TNF- α the significance of CD44 expression in patients with malignant brain tumors [J]. Chinese Pharmacoeconomics, 2013, (04): 282-283.
[12] Meng Jian, Liu Chunyun, Zhang Wenyan, etc. Effects of lipoic acid on intercellular adhesion molecule-1 and tumor necrosis factor in experimental autoimmune encephalomyelitis rats- α Research on the effects of blood-brain barrier [C]// The Neurology Branch of the Chinese Medical Association Compilation of papers from the 11th National Conference on Neurology Institute of Brain Science, Shanxi Datong University; 2008:2.
[13] Ling Fang, Zhan Liying. Changes in serum peripheral blood tumor necrosis factor and cell adhesion molecule levels in patients with cerebral infarction [J]. Journal of Clinical Internal Medicine, 2008, (02): 125-126.
[14] Wang Xinyu, Mao Jian, Liu Suying. Intrauterine infection causing fetal mouse brain TNF- α A study on expression and changes in brain cell apoptosis [J]. Journal of China Medical University, 2006, (05): 491-493.

Subscription
E-Mail Alert
Most popular papers
Call for Special Issue
Publication Ethics & OA Statement
Plagiarism Policy
Contact Us
Downloads: 427
Visits: 28423

Sponsors, Associates, and Links

All published work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2016 - 2031 Clausius Scientific Press Inc. All Rights Reserved.