Author(s)

Zhengjie Hao ¹

Affiliation(s)

¹ Tsinghua International School Daoxiang Lake, Daoxiang Lake School, Ningcui Road, Haidian District, Beijing, China

Corresponding Author

Zhengjie Hao

ABSTRACT

To investigate the difference in toxicity between polyvinyl chloride (PVC) and polystyrene sulfonic acid (PS), this study tests the toxicity of PVC and PS on NCM460 cells. NCM460 cells are located in the human colonic epithelium. By testing these two different microplastics at various concentrations and exposure times (e.g., 2 hours and 24 hours), the CCK-8 assay results show that PS is a safer material for intestinal cells than PVC. This work provides theoretical and experimental evidence for evaluating the risk of microplastics to intestinal cells.

KEYWORDS

Microplastic; intestinal cells; cytotoxicity

CITE THIS PAPER

Zhengjie Hao, Toxicity of micromilimeter of polyvinly chloride and polystyrene sulfonic acid microplastics toward NCM460 cells. MEDS Basic Medicine (2025) Vol. 3: 37-41. DOI: http://dx.doi.org/10.23977/medbm.2025.030107.

REFERENCES

[1] Patil, U.A., Kubade, P.R. Exploring Health Risks of PVC and Investigating Potential Alternatives Through Mechanical Analysis and Simulation. J. Inst. Eng. India Ser. C 105, 1571–1580 (2024). https://doi.org/10.1007/s40032-024-01117-0
[2] Qin, Lingfeng, et al. "Comparison of the toxic effects of polystyrene and sulfonated polystyrene on wheat under cadmium stress." Journal of Hazardous Materials 474(2024).
[3] Kumar R, Manna C, Padha S, Verma A, Sharma P, Dhar A, Ghosh A, Bhattacharya P. Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans? Chemosphere. 2022 Jul;298: 134267. doi: 10.1016/j.chemosphere.2022.134267. Epub 2022 Mar 14. PMID: 35301996.
[4] Xiaoqian, Feng, et al. "#2767 Micro(nano)plastics are exposed and bioaccumulated in human fetus—the first evidence from neonatal umbilical cord blood and urine." Nephrology Dialysis Transplantation Supplement_1(2024): Supplement 1. 
[5] Khan L, Ghias S, Zafar MI, et al. Exploration of microplastic pollution with particular focus on source identification and spatial patterns in riverine water, sediment and fish of the Swat River, Pakistan. RSC Adv. 2022;12(16):9556-9566.
[6] Burighel, Paolo, and C. Milanesi. "Fine structure of the intestinal epithelium of the colonial ascidian Botryllus schlosseri." Cell and Tissue Research 182.3(1977):357-369.

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