Author(s)

Xiaofei Zhang ¹

Affiliation(s)

¹ College of Food Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, China

Corresponding Author

Xiaofei Zhang

ABSTRACT

This study investigates the differential regulatory mechanisms of polysaccharide-based, protein-based, and liposome-mediated probiotic delivery systems in maintaining intestinal barrier homeostasis. By analyzing the physicochemical properties of these three carrier types and their interactions with probiotics, the research reveals how carrier materials influence barrier function through molecular pathways including regulation of tight junction protein expression, activation of goblet cells, and polarization of immune cells. Polysaccharide carriers demonstrate sustained release and immune modulation effects, protein-based carriers enhance microbial colonization through targeted release, while liposomes prioritize activation of epithelial repair signaling. The synergistic interaction between carrier degradation products and microbial metabolites further optimizes the intestinal microenvironment. Future delivery system design should integrate material properties with host-microbiota interaction networks to achieve precise and long-term regulation of intestinal barriers.

KEYWORDS

Probiotic Delivery System; Intestinal Barrier Function; Carrier Materials; Immune Regulation; Microbe-Host Interaction

CITE THIS PAPER

Xiaofei Zhang, Study on the Difference of Intestinal Barrier Function and Homeostasis Regulation by Different Vectors-Mediated Probiotics Delivery. Advances in Food Science and Human Nutrition (2025) Vol.7: 54-59. DOI: http://dx.doi.org/10.23977/afshn.2025.070108.

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Sponsors, Associates, and Links

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• Journal of Modern Crop Science
  
  
• Plant Nutrition & Soil Science International
  
  
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