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  4. Vol 5, Issue 3, 2023

The Mechanism of Action and Research Progress of Xuefu Zhuyu Decoction Against Liver Cancer

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DOI: 10.23977/medcm.2023.050305 | Downloads: 8 | Views: 389

Author(s)

Hongmei Li 1, Zhenjia Huang 1, Yuan Liu 1, Xianliang Hong 1, Renting Li 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712046, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, 712000, China

Corresponding Author

Renting Li

ABSTRACT

Xuefu Zhuyu decoction comes from Wang Qingren's "Medical Forest Correcting Mistakes" which can be used for the treatment of qi stagnation and blood stasis, and is currently widely used in the treatment of liver fibrosis and liver cancer. This article summarizes the mechanism of anti-liver cancer from six aspects, including regulating the cell cycle, inhibiting inflammatory factors, enhancing antioxidant capacity, controlling tumor angiogenesis, regulating related signaling pathways, and regulating the body's immune ability, and finds that Xuefu Zhuyu decoction has the effects of inhibiting cell proliferation, promoting apoptosis, enhancing the body's antioxidant capacity, resisting the occurrence of inflammation, inhibiting liver cancer neovascularization, and improving the body's immunity, and participates in the regulation of signaling pathways, such as Wnt/β-catenin、TLR4/NF-κB、p38MAPK/ERK1/2. It's further confirmed that Xuefu Zhuyu decoction has anti-liver cancer effects in the molecular mechanism. It was found that this side has the effect of relieving patients' symptoms, improving patients' survival time and quality of life, from the clinical application of anti-liver cancer. Through the analysis of the current situation of the treatment of liver cancer, the shortcomings of today's research are put forward, which provides the latest ideas and basis for the in-depth research and clinical application of this side in the future. 

KEYWORDS

Xuefu Zhuyu Decoction, Liver Cancer, Mechanism of Action

CITE THIS PAPER

Hongmei Li, Zhenjia Huang, Yuan Liu, Xianliang Hong, Renting Li, The Mechanism of Action and Research Progress of Xuefu Zhuyu Decoction Against Liver Cancer. MEDS Chinese Medicine (2023) Vol. 5: 37-45. DOI: http://dx.doi.org/10.23977/medcm.2023.050305.

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