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  4. Vol 1, Issue 1, 2023

Research Progress of Urogenic Stem Cells and Exosomes in Chronic Kidney Disease

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DOI: 10.23977/medbm.2023.010106 | Downloads: 13 | Views: 564

Author(s)

Yuanmin Zhang 1, Sheng Dong 2

Affiliation(s)

1 Shaanxi University of Chinese Medicine, Xianyang, 712046, China
2 Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China

Corresponding Author

Sheng Dong

ABSTRACT

Chronic kidney disease (CKD) is a chronic metabolic disease with renal function injury or glomerular filtration rate <60% caused by a variety of factors. Due to the powerful compensatory function of the kidney, the onset of the disease is hidden, and if it cannot be detected and intervened in time, it can eventually progress to end-stage renal disease. At this time, alternative drugs such as dialysis and kidney transplantation can be used to maintain life. Urine-derivedstemceslls (USUs) are stem cells obtained from human blood with very high expansion function and multi-differentiation potential, and have the characteristics of unlimited source, non-invasive and self-derived culture. Many scientific studies have shown that USCs also has very important physiological and pathological effects in the fields of cell inflammatory response, cell apoptosis and cellular oxidative stress. Therefore, the search for potential biomarkers of chronic kidney disease has become an urgent problem. In this paper, the origin, isolation and culture of urogenic stem cells, their application in chronic kidney disease and the research progress of exosomes were reviewed.

KEYWORDS

Chronic kidney disease, urinary stem cells, exosome, miRNA

CITE THIS PAPER

Yuanmin Zhang, Sheng Dong, Research Progress of Urogenic Stem Cells and Exosomes in Chronic Kidney Disease. MEDS Basic Medicine (2023) Vol. 1: 29-33. DOI: http://dx.doi.org/10.23977/medbm.2023.010106.

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