Author(s)

Qianlong Wang, Jichao Dai

Corresponding Author

Qianlong Wang

ABSTRACT

Nowadays, the increasing use of multivalent molecules for therapy has proved that they play a significant role in clinical application. The multivalent combination provides a wide range of advantages and unique functions that monovalent interactions cannot achieve. Multivalent interaction is collectively much stronger than monovalent interaction. Specifically speaking, multivalent ligands bind tighter to their respective multivalent receptors, including pathogens (viruses, bacteria), toxins, lectins, ion channels, enzymes and cell surface receptors, due to the structure of the molecules, which can ligand with more receptors. Here, this paper introduces the basic mechanism of the multivalent interaction and reviews the applications of the multivalent molecules in cellar targets and bacteria or virus inhibition. If more multivalent molecules would be synthetic to understand cell transduction and treat patients, this technology will have a strong potential in medical application.

KEYWORDS

Multivalent Molecules, interaction mechanism, medical application, therapy