Author(s)

Jiewen Zheng

Corresponding Author

Jiewen Zheng

ABSTRACT

Based on the unique advantages of nanomaterials, they have been considered as attractive biomedical devices in cancer nanomedicine. When exposed to the biological milieu, nanoparticles would inevitably interact with biomolecules and generate a protein coating layer called the 'protein corona'. Protein corona has been proven to be decisive in nanoparticle biological fate and following cellular responses by enriching low abundant proteins in the biological fluid. However, the comprehension of nanoparticle-protein corona complex still remains insufficient, which would result in the limitation of nano-based therapeutics development or even induce cytotoxicity to normal cells. This paper mainly focuses on protein corona's dynamic properties and intracellular mechanisms in nano-bio interactions and its applications in cancer nanomedicine, including targeted drug delivery, biomarker discovery, and personalized precision medicine. Understanding the specific role of protein corona would advance the discovery of potential drug targets and the design of novel nano-based theranostics strategies. Thereafter, the modification and control of the nanoparticle surface and the components of the protein corona are supposed to provide high-precision detection and promising therapeutic effects to predict and enhance cancer treatment.

KEYWORDS

Protein corona, Nano-bio interaction, Cancer nanomedicine, Nano-drug delivery, Biomarker discovery